NEUROLOGICAL DEFICIT AND EXTENT OF NEURONAL NECROSIS ATTRIBUTABLE TO MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS - STATISTICAL VALIDATION
NEUROLOGICAL DEFICIT AND EXTENT OF NEURONAL NECROSIS ATTRIBUTABLE TO MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS - STATISTICAL VALIDATION
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DOI：
10.1161/01.str.26.4.627
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发表时间：
1995-04-01
期刊：
影响因子：
8.3
通讯作者：
HU, XJ
中科院分区：
文献类型：
--
作者：
GARCIA, JH;WAGNER, S;HU, XJ
背景和目的：大鼠颅内大动脉闭塞后，脑损伤的发生与坏死神经元的表面积和数量的增加有关。本研究探讨是否再灌注缺血领土30至60分钟后，动脉闭塞将有一个有益的影响，无论是临床或组织学结果的lesion.Methods一百零四只成年大鼠（包括适当的控制）被使用; 97有一个大脑中动脉闭塞插入尼龙单丝通过右颈外动脉。动脉闭塞在两组中是短暂的，在另一组中是永久的;所有组的生存时间相当。对对照动物进行假手术，在此期间动脉闭塞不到1分钟。结果与永久性动脉闭塞组相比，短暂性动脉闭塞组（30 ~ 60 min）的神经功能缺损程度和皮质坏死神经元的平均数目明显增加（P
Background and Purpose Occluding a large intracranial artery in rats produces a brain lesion that grows in terms of an increase in both surface area and number of necrotic neurons. The present study investigated whether reperfusing the ischemic territory 30 to 60 minutes after the arterial occlusion would have a beneficial effect on either the clinical or the histological outcome of the lesion.Methods One hundred four adult rats (including appropriate controls) were used; 97 had a middle cerebral artery occluded by inserting a nylon monofilament via the right external carotid artery. The arterial occlusion was transient in two groups and permanent in another; survival times were comparable for all groups. Control animals were subjected to a sham operation during which the artery was occluded for less than 1 minute. The outcome was evaluated by measuring the extent of the neurological deficit and the severity of the histological injury.Results Mean neurological score and mean number of necrotic neurons in the cortex were more favorable after transient (30- to 60-minute) compared with permanent arterial occlusion (P