1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery
1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery
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DOI：
10.1002/anie.201703801
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发表时间：
2017-07-17
影响因子：
16.6
通讯作者：
Mykhailiuk, Pavel K.
中科院分区：
文献类型：
--
作者：
Kirichok, Alexander A.;Shton, Iryna;Mykhailiuk, Pavel K.
2-取代的哌啶核存在于药物中（18种FDA批准的药物），然而，它们的螺环类似物仍然未知。本文介绍了2-取代哌啶的螺环类似物的合成及其在药物发现中的验证。
The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their validation in drug discovery.