Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen
Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen
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DOI：
10.1111/j.1439-0450.2006.00968.x
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发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Beutin, L.
中科院分区：
文献类型：
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作者：
Beutin, L.
产滋贺毒素（Stx）[Verotoxin（VT）]的大肠埃希菌（STEC），又称肠出血性大肠埃希菌（enterohemorrhagic E.大肠杆菌或VTEC是新兴的人畜共患病病原体，并且成为人类病原体中最重要的病原体，特别是在工业化国家。细胞毒素（也称为Stx或VT）的产生是STEC的主要致病性决定因素，STEC可在人类中引起危及生命的出血性疾病。STEC表型的谱是多样的，家养动物和野生动物构成这些细菌的重要储存库。STEC从动物粪便传播到环境、水和食物。摄入受污染的食物和水，以及与环境、排泄STEC的动物或人类接触，是人类感染的主要来源。动物和食品生产的经济变化、消费者习惯的改变以及缺乏特异性免疫反应，特别是在城市化人群中，导致了最近STEC作为人畜共患病病原体的传播。超国家监测网络以及作为哨兵的国家参考实验室在预防和控制人类STEC感染方面发挥着重要作用。新疫苗和益生菌的开发可能成为未来控制STEC在动物和人类中传播的工具。
Shiga toxin (Stx) [Verotoxin (VT)]-producing Escherichia coli (STEC), also called enterohaemorrhagic E. coli or VTEC are emerging zoonotic agents and became most important as human pathogens, particularly in the industrialized countries. Production of cytotoxins, also called Stx or VT, is the major pathogenicity determinant of STEC, which can cause life-threatening haemorrhagic diseases in humans. The spectrum of STEC phenotypes is diverse and domestic and wildlife animals constitute important reservoirs for these bacteria. STEC are spread from animal faeces to the environment, water and food. Ingestion of contaminated foodstuff and water, as well as contact with the environment, STEC-excreting animals or humans are the major sources of human infection. Economical changes in animal and food production, alteration of consumer habits and lack of specific immune response, particularly in urbanized populations, have contributed to the recent spread of STEC as a zoonotic agent. Supranational surveillance networks as well as national reference laboratories as sentinels play an important role in the prevention and control of STEC infections in humans. Development of new vaccines and probiotics may serve as future tools to control the spread of STEC in animals and humans.