Reality monitoring and visual hallucinations in Parkinson's disease
Reality monitoring and visual hallucinations in Parkinson's disease
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DOI：
10.1016/s0028-3932(02)00182-3
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
David, AS
中科院分区：
文献类型：
--
作者：
Barnes, J;Boubert, L;David, AS
8 - 40%的帕金森病（PD）患者在病程中会出现幻视（VH）。虽然认知障碍已被确定为幻觉的一个危险因素，更具体的神经心理缺陷的基础上，这种现象还没有建立。精神病理学的研究表明，幻觉与事件的内部表征和真实的事件（即受损源监测）之间的混淆有关。我们评估了三组：对17例有幻视的帕金森病患者、20例无幻视的帕金森病患者和20例年龄匹配的对照者进行视觉表象、视知觉和记忆测试，包括源监测和回忆体验测试。这项研究表明，有幻觉的帕金森病患者似乎有完整的视觉成像过程和空间感知。然而，与非幻觉性帕金森病患者和健康对照组相比，对象感知和识别记忆受损，对编码事件的回忆较差。当编码和提取线索处于不同的模式时，错误特别容易发生。研究结果提出了帕金森病患者的幻视可能源于对环境刺激的错误感知处理，以及对经验的不详细回忆与完整图像生成的结合。(C)2002年爱思唯尔科学有限公司保留所有权利。
Between 8 and 40% of Parkinson disease (PD) patients will have visual hallucinations (VHs) during the course of their illness. Although cognitive impairment has been identified as a risk factor for hallucinations, more specific neuropsychological deficits underlying such phenomena have not been established. Research in psychopathology has converged to suggest that hallucinations are associated with confusion between internal representations of events and real events (i.e. impaired-source monitoring). We evaluated three groups: 17 Parkinson's patients with visual hallucinations, 20 Parkinson's patients without hallucinations and 20 age-matched controls, using tests of visual imagery, visual perception and memory, including tests of source monitoring and recollective experience. The study revealed that Parkinson's patients with hallucinations appear to have intact visual imagery processes and spatial perception. However, there were impairments in object perception and recognition memory, and poor recollection of the encoding episode in comparison to both non-hallucinating Parkinson's patients and healthy controls. Errors were especially likely to occur when encoding and retrieval cues were in different modalities. The findings raise the possibility that visual hallucinations in Parkinson's patients could stem from a combination of faulty perceptual processing of environmental stimuli, and less detailed recollection of experience combined with intact image generation. (C) 2002 Elsevier Science Ltd. All fights reserved.