Cell Type-Specific Induction and Inhibition of Apoptosis by Herpes Simplex Virus Type 2 ICP10
Cell Type-Specific Induction and Inhibition of Apoptosis by Herpes Simplex Virus Type 2 ICP10
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DOI：
10.1128/jvi.02088-08
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发表时间：
2009-03-15
影响因子：
5.4
通讯作者：
Jerome, Keith R.
中科院分区：
文献类型：
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作者：
Han, Jin-Young;Miller, Sara A.;Jerome, Keith R.
单纯疱疹病毒（HSV）抑制外部刺激诱导的上皮细胞凋亡。相反，细胞凋亡是单纯疱疹病毒感染淋巴细胞的主要结果。在这里，我们发现HSV 2型（HSV-2）基因表达似乎是诱导Jurkat细胞（一种t细胞白血病系）凋亡所必需的。HSV-2 ICP10基因表达足以诱导Jurkat细胞凋亡，而其表达可保护上皮HEp-2细胞免受环己亚胺和肿瘤坏死因子α引发的凋亡。因此，HSV-2基因表达对细胞凋亡通路的影响似乎取决于特定的细胞类型。
Herpes simplex virus (HSV) inhibits apoptosis induced by external stimuli in epithelial cells. In contrast, apoptosis is the primary outcome in HSV-infected lymphocytes. Here, we show that HSV type 2 (HSV-2) gene expression appears to be necessary for the induction of apoptosis in Jurkat cells, a T-cell leukemia line. HSV-2 ICP10 gene expression is sufficient to induce apoptosis in Jurkat cells, while its expression protects epithelial HEp-2 cells from apoptosis triggered by cycloheximide and tumor necrosis factor alpha. Thus, the effect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell type.