NORMAL DEPOSITION OF BRAIN IRON IN CHILDHOOD AND ADOLESCENCE - MR IMAGING AT 1.5 T
NORMAL DEPOSITION OF BRAIN IRON IN CHILDHOOD AND ADOLESCENCE - MR IMAGING AT 1.5 T
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DOI：
10.1148/radiology.172.2.2748819
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发表时间：
1989-08-01
期刊：
影响因子：
19.7
通讯作者：
NORMAN, D
中科院分区：
文献类型：
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作者：
AOKI, S;OKADA, Y;NORMAN, D
对285例2~25岁儿童的脑部磁共振(MR)图像进行了回顾性研究，以确定脑铁蓄积的表现。对苍白球、红核、黑质和齿状核进行长时间/长时间(重复时间/回声时间)自旋回波序列检查，并进行分期。在大多数患者中，所有四个区域最初与白质相比都是高信号(阶段I)，然后变成等信号(阶段II)和随后的低信号(阶段III)。苍白球最先进入第三阶段，其次是红核和黑质，最后是齿状核。一般来说，在10岁以下的患者中，这些区域的信号强度降低(III期)并不明显；大多数患者在25岁之前就可以看到信号强度降低。齿状核的信号强度下降得更慢，而且不一致；只有三分之一的患者在25岁时达到了III期。磁共振成像检测到的正常铁沉积的时间序列不仅有助于诊断已知的铁沉积疾病，而且有助于检测与铁相关的病理变化。
Magnetic resonance (MR) images of the brain in 285 patients between the ages of 2 and 25 years were retrospectively studied to determine the appearance of brain iron accumulation. The globus pallidus, red nucleus, substantia nigra, and dentate nucleus were evaluated with long TR/TE (repetition time/echo time) spin-echo sequences and staged. All four regions in most patients were initially hyperintense compared with white matter (stage I) before becoming isointense (stage II) and subsequently hypointense (stage III). The globus pallidus was the first to reach stage III, the red nucleus and substantia nigra were next, and the dentate nucleus was last. In general, decreased signal intensity (stage III) was not seen in these regions in patients less than 10 years old; in most patients it was seen by age 25 years. The dentate nucleus decreased in signal intensity more slowly and inconsistently; only one-third of patients had reached stage III by age 25 years. The temporal sequence of normal iron deposition as detected with MR imaging is helpful not only in the diagnosis of known iron-deposition diseases but also in the detection of iron-related pathologic changes.