Blood vessels restrain pancreas branching, differentiation and growth
Blood vessels restrain pancreas branching, differentiation and growth
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DOI：
10.1242/dev.066548
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发表时间：
2011-11-01
期刊：
影响因子：
4.6
通讯作者：
Dor, Yuval
中科院分区：
文献类型：
--
作者：
Magenheim, Judith;Ilovich, Ohad;Dor, Yuval
How organ size and form are controlled during development is a major question in biology. Blood vessels have been shown to be essential for early development of the liver and pancreas, and are fundamental to normal and pathological tissue growth. Here, we report that, surprisingly, non-nutritional signals from blood vessels act to restrain pancreas growth. Elimination of endothelial cells increases the size of embryonic pancreatic buds. Conversely, VEGF-induced hypervascularization decreases pancreas size. The growth phenotype results from vascular restriction of pancreatic tip cell formation, lateral branching and differentiation of the pancreatic epithelium into endocrine and acinar cells. The effects are seen both in vivo and ex vivo, indicating a perfusionin-dependent mechanism. Thus, the vasculature controls pancreas morphogenesis and growth by reducing branching and differentiation of primitive epithelial cells.
