Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.
Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.
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DOI：
10.1016/j.pbb.2012.09.015
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发表时间：
2012-12
影响因子：
3.6
通讯作者：
See, Ronald E.
中科院分区：
文献类型：
--
作者：
Gabriele, Amanda;Pacchioni, Alejandra M.;See, Ronald E.
有证据表明，可卡因成瘾可能涉及背外侧尾壳核（dlCPu）的渐进性神经适应性变化。虽然长期自我给药戒断后寻求可卡因需要完整的dlCPu功能，但尚未研究dlCPu中的体内神经递质释放。目前的研究测量了在有限或延长的禁欲之后的药物寻求期间以及响应于单独的可卡因引发注射的dlCPu多巴胺（DA）和谷氨酸（GLU）释放。雄性Sprague-Dawley大鼠自我给予可卡因（0.2 mg/50 µl输注，i. v.）10天（2小时/天）。在体内微透析发生在自我管理室后1和14天的禁欲（实验1）。完成自我给药的单独一组动物以及未用药对照组在并行微透析期间接受可卡因引发注射（20 mg/kg）（实验2）。DA释放增加在药物寻求在自我管理的情况下，在1和14天后禁欲。相反，GLU释放仅在禁欲1天后增加。此外，与药物初治对照组相比，具有可卡因自我给药史的动物在可卡因激发后显示出增强的DA和GLU释放。这些结果表明，慢性可卡因自我给药在药物配对背景和药物引发条件下均增强dlCPu DA和GLU。
Evidence suggests that cocaine addiction may involve progressive neuroadaptive changes in the dorsolateral caudate putamen (dlCPu). While cocaine seeking following abstinence from chronic self-administration requires intact dlCPu function, in vivo neurotransmitter release in the dlCPu has not been investigated. The current study measured dlCPu dopamine (DA) and glutamate (GLU) release during drug seeking following limited or extended abstinence, as well as in response to a cocaine priming injection alone. Male, Sprague-Dawley rats self-administered cocaine (0.2 mg/50 µl infusion, i.v.) for 10 days (2-h/day). In vivo microdialysis occurred in the self-administration chamber after 1 and 14 days of abstinence (experiment 1). A separate set of animals that completed self-administration as well as drug naïve controls received a cocaine priming injection (20 mg/kg) during concurrent microdialysis (experiment 2). DA release increased during drug seeking in the self-administration context at both 1 and 14 days post abstinence. In contrast, GLU release only increased after 1 day of abstinence. Furthermore, animals with a cocaine self-administration history showed enhanced DA and GLU release following cocaine challenge as compared to drug naïve controls. These results indicate that chronic cocaine self-administration enhances dlCPu DA and GLU under both drug-paired context and drug-primed conditions.
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影响因子：
5.3
作者：
Bamford, NS;Robinson, S;Meshul, CK
通讯作者：
Meshul, CK
影响因子：
4.7
作者：
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通讯作者：
Parsons, LH
影响因子：
5.6
作者：
Briand, Lisa A.;Flagel, Shelly B.;Robinson, Terry E.
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影响因子：
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作者：
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DOI：
10.1098/rstb.1971.0102
发表时间：
1971-01-01
影响因子：
6.3
作者：
KEMP, JM;POWELL, TPS
通讯作者：
POWELL, TPS