The normal environment delays the development of multisensory integration.
The normal environment delays the development of multisensory integration.
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正常环境会延迟多感觉统合的发展
DOI：
10.1038/s41598-017-05118-1
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发表时间：
2017-07-06
影响因子：
4.6
通讯作者：
Stein BE
中科院分区：
文献类型：
--
作者：
Xu J;Yu L;Rowland BA;Stein BE
动物的多感觉神经元在早期生活中，跨模式体验受损，无法发展跨这些感官整合信息的能力。因此，它们缺乏增加提供聚合跨模态输入的事件的生理显著性的能力。本研究表明，在受控的实验室模式下，周期性地暴露于一组单一的视觉-听觉刺激下，视觉-听觉体验在生命早期因噪声饲养而受损的动物的上丘（SC）神经元可以迅速发展视觉-听觉多感觉整合能力。然而，如果他们的经历仅限于正常的住房环境，他们仍然会受到损害。考虑到多感觉整合能力通常是在生命早期在正常环境中发展起来的，在正常环境中，各种各样的感觉刺激促进了神经轴多个层次复杂神经回路的功能组织，这些观察结果似乎是违反直觉的。然而，正常环境中感官刺激的丰富性和内在可变性将导致任何给定的一组跨模态线索的不太规律的耦合，而不是“贫乏”的实验室暴露范式。这对新生儿没有明显的问题，但对成年人却有，这表明了多感觉整合能力发展需求的成熟转变。
Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cross-modal inputs. The present study demonstrates that superior colliculus (SC) neurons in animals whose visual-auditory experience is compromised early in life by noise-rearing can develop visual-auditory multisensory integration capabilities rapidly when periodically exposed to a single set of visual-auditory stimuli in a controlled laboratory paradigm. However, they remain compromised if their experiences are limited to a normal housing environment. These observations seem counterintuitive given that multisensory integrative capabilities ordinarily develop during early life in normal environments, in which a wide variety of sensory stimuli facilitate the functional organization of complex neural circuits at multiple levels of the neuraxis. However, the very richness and inherent variability of sensory stimuli in normal environments will lead to a less regular coupling of any given set of cross-modal cues than does the otherwise “impoverished” laboratory exposure paradigm. That this poses no significant problem for the neonate, but does for the adult, indicates a maturational shift in the requirements for the development of multisensory integration capabilities.