Selective synthesis of secondary and tertiary amines by cp*iridium-catalyzed multialkylation of ammonium salts with alcohols.
Selective synthesis of secondary and tertiary amines by cp*iridium-catalyzed multialkylation of ammonium salts with alcohols.
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DOI：
10.1055/s-2008-1042823
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发表时间：
2008-01
期刊：
影响因子：
5.2
通讯作者：
R. Yamaguchi;Shoko Kawagoe;Chiho Asai;K. Fujita
中科院分区：
文献类型：
--
作者：
R. Yamaguchi;Shoko Kawagoe;Chiho Asai;K. Fujita
在无溶剂条件下，Cp~(2+)Ir催化的铵盐与醇的多烷基化反应实现了仲胺和叔胺的高效选择性合成：醋酸铵与醇的反应只生成叔胺，而四氟硼酸铵则选择性地生成仲胺。利用该方法，以四氟硼酸铵和二醇为原料，在一锅中合成了5元环胺和6元环胺。
The efficient selective synthesis of secondary and tertiary amines has been achieved by means of Cp*Ir-catalyzed multialkylation of ammonium salts with alcohols without solvent: the reactions of ammonium acetate with alcohols gave tertiary amines exclusively, while those of ammonium tetrafluoroborate afforded secondary amines selectively. Using this method, secondary 5- and 6-membered cyclic amines were synthesized from ammonium tetrafluoroborate and diols in one pot.