Antiphospholipid antibodies in response to infection.
Antiphospholipid antibodies in response to infection.
复制标题
DOI：
10.1007/s11926-007-0034-x
复制
发表时间：
2007-06-01
影响因子：
5
通讯作者：
Toplak, Natasa
中科院分区：
文献类型：
--
作者：
Avcin, Tadej;Toplak, Natasa
一些流行病学和实验研究表明，感染与抗磷脂抗体(APL)之间存在关联。感染诱发的APL传统上被认为是一过性的，通常与抗磷脂综合征的临床特征无关。根据结合辅因子的要求区分自身免疫和感染后急性早幼粒细胞白血病并不是绝对的，近年来的一些报道表明，一些患者可以产生致病抗体来应对感染。最常见的与抗磷脂综合征相关的感染包括微小病毒B19、巨细胞病毒、水痘-带状疱疹病毒、艾滋病毒、链球菌和葡萄球菌感染、革兰氏阴性菌和肺炎支原体。
An association between infections and antiphospholipid antibodies (aPL) has been reported in several epidemiologic and experimental studies. Infection-induced aPL have been traditionally regarded as transient and were generally not associated with clinical features of antiphospholipid syndrome. The distinction between autoimmune and postinfectious aPL on the basis of requirement of binding cofactor is not absolute, and in recent years, several reports demonstrated that some patients can produce pathogenic antibodies in response to infection. Infections most frequently associated with antiphospholipid syndrome include parvovirus B19, cytomegalovirus, varicella-zoster virus, HIV, streptococcal and staphylococcal infections, gram-negative bacteria, and Mycoplasma pneumoniae.