Editorial: Platelet Secretion.
Editorial: Platelet Secretion.
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社论：血小板分泌。
DOI：
10.1080/09537104.2016.1277676
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发表时间：
2017
期刊：
影响因子：
3.3
通讯作者：
Whiteheart,SidneyW
中科院分区：
文献类型：
--
作者：
Storrie,Brian;Whiteheart,SidneyW
对于血小板研究人员来说，这是振奋人心的时刻。通过应用新技术（如高分辨率成像、质谱分析和DNA/RNA分析），我们不断发现血小板生物学的新方面；它们对血小板功能有惊人的影响。越来越清楚的是，血小板能够进行许多细胞过程。mRNA剪接、翻译、内吞、自噬和胞吐。这些发现表明，血小板比以前认识到的更有活力，并阐明了血小板不仅有助于止血，还有助于免疫反应的机制。在这篇综述中，我们调查了关于血小板及其分泌颗粒的令人兴奋的新发现。我们检查颗粒的形成，内容，结构和分泌及其对血小板功能的影响。分泌是血小板对刺激作出反应，从致密（δ）颗粒、α (α)颗粒和分泌溶酶体三种储存颗粒中释放货物的过程。这是使血小板对血管损伤和感染部位的微环境产生深远影响的关键过程。血小板分泌功能障碍具有重要的临床意义。所包括的综述讨论了血小板颗粒的结构和
These are exhilarating times for platelet researchers. Through the applications of new technologies (eg, high resolution imaging, mass spectrometry, and DNA/RNA profiling), we continue to discover new facets of platelet biology; ones that have surprising effects on platelet function. It is increasingly clear that platelets are capable of many cellular processes ie. mRNA splicing, translation, endocytosis, autophagy, and exocytosis. These discoveries have shown that platelets are much more dynamic than was perhaps previously appreciated and have illuminated the mechanisms by which platelets not only contribute to hemostasis but also to immune responses.In this collection of reviews, we survey the exciting new discoveries about platelets and their secretory granules. We examine granule formation, content, structure and secretion and their implications for platelet function. Secretion is the process by which platelets, in response to stimulation, release cargo from three classes of storage granules: dense (δ) granules, alpha (α) granules, and secretory lysosomes. This is a key process that enables platelets to have profound effects on the microenvironments at sites of vascular damage and infection. Dysfunction in platelet secretion has significant clinical ramifications. The included reviews discuss the structures of platelet granules and