Increased nocturnal interleukin-6 excretion in patients with primary insomnia: A pilot study
Increased nocturnal interleukin-6 excretion in patients with primary insomnia: A pilot study
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DOI：
10.1016/j.bbi.2005.06.007
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发表时间：
2006-05-01
影响因子：
15.1
通讯作者：
Riemann, D
中科院分区：
文献类型：
--
作者：
Burgos, I;Richter, L;Riemann, D
本研究的目的是调查原发性失眠患者与对照组相比，夜间/夜间白细胞介素-6（IL-6）血清排泄是否存在差异。我们假设，在失眠症患者中，夜间/夜间IL-6的排泄增强，就像在老年人和健康受试者睡眠剥夺后观察到的那样。我们研究了原发性失眠患者（2名男性和9名女性）和年龄和性别匹配的健康对照组的IL-6血清浓度。睡眠监测多导睡眠连续三个晚上。在最后一个实验室夜晚之前和期间，以2小时间隔测量IL-6（从19：00 h至09：00 h）。多导睡眠图确定的睡眠参数和睡眠的主观评级表明，失眠症组的睡眠明显受损。夜间IL-6分泌显著增加（p
The aim of the present study was to investigate whether there is a difference in evening/nocturnal interleukin-6 (IL-6) serum excretion in patients with primary insomnia compared to controls. We hypothesized that in insomniac patients, the excretion of evening/ nocturnal IL-6 is enhanced, like observed in aged adults and after sleep deprivation in healthy subjects. We studied IL-6 serum concentrations in I I patients (two males and nine females) with primary insomnia and I I age and gender-matched healthy controls. Sleep was monitored polysomnographically for three consecutive nights. The measurement of IL-6 (from 19:00 h to 09:00 h) in 2-h intervals were performed prior to and during the last laboratory night. Polysomnographically determined sleep parameters and subjective ratings of sleep demonstrated clear-cut impairments of sleep in the insomniac group. Nocturnal IL-6 secretion was significantly increased (p