Basic fibroblast growth factor (bFGF) regulation of the plasma membrane calcium ATPase (PMCA) as part of an anti-apoptotic mechanism of action.
Basic fibroblast growth factor (bFGF) regulation of the plasma membrane calcium ATPase (PMCA) as part of an anti-apoptotic mechanism of action.
复制标题
碱性成纤维细胞生长因子 (bFGF) 对质膜钙 ATP 酶 (PMCA) 的调节是抗凋亡作用机制的一部分。
DOI：
10.1016/s0006-2952(03)00486-6
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发表时间：
2003
影响因子：
5.8
通讯作者：
Peluso,JohnJ
中科院分区：
文献类型：
--
作者：
Peluso,JohnJ
Basic fibroblast growth factor (bFGF) preserves the viability of at least 13 different cells, including epithelial, endothelial, smooth muscle and neuronal cells. In spite of this profound and rather universal effect on cell viability, detailed studies regarding the mechanism of bFGF’s action have not been conducted. Rather, most studies have simply shown that bFGF inhibits cells from undergoing programmed cell death (i.e. apoptosis). The most mechanistic studies to date have been conducted on either neurons or ovarian (granulosa) cells. These studies have shown that bFGF prevents apoptosis through both genomic and acute actions. Basic FGF’s acute actions involved the maintenance of normal levels of intracellular free calcium levels ([Ca2+]i). In granulosa cells, bFGF maintained [Ca2+]ithrough a protein kinase Cdelta(PKCδ)-dependent mechanism. Further, bFGF-activated PKCδ maintained [Ca2+]iby stimulating calcium efflux. The ability of bFGF to stimulate calcium efflux involved the plasma membrane calcium ATPase (PMCA). Interestingly, bFGF-activated PKCδ appeared to regulate PMCA activity in part by promoting its membrane localization.
