Plastic neuronal probes for implantation in cortical and subcortical areas of the rat brain
Plastic neuronal probes for implantation in cortical and subcortical areas of the rat brain
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DOI：
10.1504/ijnt.2012.045351
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发表时间：
2012-01-01
影响因子：
0.5
通讯作者：
Malliaras, George G.
中科院分区：
文献类型：
--
作者：
Ismailova, Esma;Doublet, Thomas;Malliaras, George G.
我们讨论了用于记录大鼠脑内神经元活动的柔性植入式探针的制造。我们使用聚酰亚胺作为衬底，SU-8作为绝缘层，制作了这种带有12个铂电极的探针。采用激光烧蚀法确定探针轮廓，简化了制作工艺。该探针不仅具有良好的机械柔韧性，而且具有植入所需的刚度。组织学结果和神经元活动的电记录支持聚酰亚胺和SU-8的组合代表了制造植入式神经元探针的良好选择的想法。
We discuss the fabrication of flexible implantable probes for recording neuronal activity in the rat brain. We fabricated such probes bearing 12 platinum electrodes, using polyimide as a substrate and SU-8 as an insulation layer. The fabrication process was simplified through the use of laser ablation to define the probe outline. The probes showed not only good mechanical flexibility but also the required stiffness for implantation. Histology results and electrical recordings of neuronal activity lend support to the idea that the combination of polyimide and SU-8 represents a good choice of materials for the fabrication of implantable neuronal probes.