Enhanced angiogenesis of growth factor-free porous biodegradable adhesive made with hexanoyl group-modified gelatin
Enhanced angiogenesis of growth factor-free porous biodegradable adhesive made with hexanoyl group-modified gelatin
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己酰基改性明胶制成的无生长因子多孔可生物降解粘合剂增强血管生成
DOI：
10.1016/j.biomaterials.2015.06.003
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发表时间：
2015
期刊：
影响因子：
14
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Yoshizawa;K.; Ryo;M.; Taguchi;T.
研究了经Hx：C6基团修饰的碱处理明胶（HxAlGltn）多孔膜（（P）HxAlGltn）在猪肠表面的键合行为。采用盐浸法制备了不同固液比的（P）HxAlGltns。（P）HxAlGltns比多孔AlGltn膜（（P）AlGltns）更强地结合到猪肠表面。在（P）HxAlGltns上培养的L929细胞比在（P）AlGltns上培养的细胞显示出粘附性。植入大鼠皮下组织后，观察到更快的组织浸润和更短的降解时间的高度多孔（P）HxAlGltns。血管生成标志物CD 34和α-SMA在高孔隙度的（P）HxAlGltns周围高表达。这些结果表明，高度多孔的（P）HxAlGltns不仅在湿软组织上的结合强度方面具有优势，而且在血管生成方面也具有优势。
The bonding behavior of hexanoyl (Hx: C6) group-modified alkaline-treated gelatin (HxAlGltn) porous films ((P)HxAlGltn) on the porcine intestine was evaluated. (P)HxAlGltns with various porosities were prepared by the salt-leaching method for various solid–liquid ratios. (P)HxAlGltns bonded more strongly to porcine intestine surfaces than did porous AlGltn films ((P)AlGltns). L929 cells cultured on (P)HxAlGltns showed adhesivity than cells cultured on (P)AlGltns. Faster tissue infiltration and a shorter degradation time of highly porous (P)HxAlGltns were observed after implantation in rat subcutaneous tissues. The angiogenic markers CD34 and α-SMA were highly expressed around (P)HxAlGltns that had high porosity. These results indicated that highly porous (P)HxAlGltns have advantages with respect to not only bonding strength on wet soft tissues, but also angiogenesis.