Ventrally emigrating neural tube cells differentiate into heart muscle.
Ventrally emigrating neural tube cells differentiate into heart muscle.
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腹侧迁移的神经管细胞分化成心肌。
DOI：
10.1006/bbrc.1998.0109
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Dai,D
中科院分区：
文献类型：
--
作者：
Sohal,GS;Ali,MM;Ali,AA;Dai,D
腹侧向外迁移的神经管细胞群已被证明沿着迷走神经迁移，并有助于胃肠道的发育。由于迷走神经也进入心脏，我们试图确定这些细胞是否迁移到心脏。神经管细胞被标记了含有LacZ基因的复制缺陷逆转录病毒载体，以永久标记它们的后代。第2天将病毒显微注射到鸡胚胎尾侧后脑的管腔内，随后对胚胎进行LacZ阳性细胞的检测。标记细胞最初被限制在神经管内。后来，它们与迷走神经一起迁移到心脏，在那里它们位于心肌。标记的细胞被鉴定为非神经脊来源的心肌细胞，并有特定的标记。结论：部分心肌细胞是从神经管细胞分化而来的。
A population of ventrally emigrating neural tube cells has been shown to migrate along the vagus nerve and contribute to the development of the gastrointestinal tract. Since the vagus also goes to the heart, we sought to determine if these cells migrated into the heart. Neural tube cells were tagged with replication-deficient retroviral vectors containing the LacZ gene, to permanently label their progeny. The virus was microinjected into the lumen of the caudal hindbrain of chick embryos on day 2. Embryos were later processed for the detection of LacZ positive cells. Labeled cells were initially confined to the neural tube. Later, they migrated in association with the vagus nerve into the heart, where they were located in the myocardium. Labeled cells were identified as cardiac muscle cells of non-neural crest origin, with specific markers. It is concluded that some cardiac muscle cells differentiate from the neural tube cells.