Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells
Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells
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DOI：
10.1096/fj.03-0301fje
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发表时间：
2004-01-01
期刊：
影响因子：
4.8
通讯作者：
Baumgartner-Parzer, SM
中科院分区：
文献类型：
--
作者：
Artwohl, M;Roden, M;Baumgartner-Parzer, SM
血浆游离脂肪酸（FFA）浓度在胰岛素抵抗状态下增加，并损害内皮功能。由于潜在的机制在很大程度上是未知的，我们检查了选定的，纯化的FFA。（100.300 μ mol/l，24.48 h）对人脐静脉内皮细胞（HUVECs）凋亡、细胞周期分布和相关基因/蛋白表达的作用。硬脂酸（而非油酸）呈时间和浓度依赖性地增加内皮细胞凋亡五倍（n=6，P
Plasma free fatty acid (FFA) concentrations are increased in states of insulin resistance and impair endothelial function. Because the underlying mechanisms are largely unknown, we examined selected, purified FFAs. (100.300 mu mol/l, 24.48 h) action on apoptosis, cell cycle distribution, and associated gene/protein expression in human umbilical vein endothelial cells (HUVECs). Stearic acid, but not oleic acid, time and concentration dependently increased endothelial apoptosis by fivefold (n=6, P