Neural changes associated with relational learning in schizophrenia.
Neural changes associated with relational learning in schizophrenia.
复制标题
精神分裂症中与关系学习相关的神经变化。
DOI：
10.1093/schbul/sbq037
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发表时间：
2010
影响因子：
6.6
通讯作者：
Holcomb,HenryH
中科院分区：
文献类型：
--
作者：
Rowland,LauraM;Griego,JacquelineA;Spieker,ElenaA;Cortes,CarlosR;Holcomb,HenryH
关系学习，即学习项目之间的关系，在精神分裂症中受损，但可以通过训练得到改善。本研究采用功能性磁共振成像技术研究了精神分裂症患者和健康对照者在关系学习任务训练前后的神经变化。尽管他们获得了相似的关系学习表现，但这些小组在训练前后表现出不同的神经激活模式。在训练之前和之后，控制关系学习网络中的参与区域，包括额叶、顶叶和内侧颞叶。控制也表现出激活减少区域和空间范围与关系学习能力，一种常见的现象，在成功的学习。与此相反，精神分裂症患者在训练前与对照组相比没有显示出阳性激活。训练后，精神分裂症受试者显示双侧顶叶下区激活的预测。与假设相反，在精神分裂症患者的训练中没有观察到海马激活。这些研究结果表明，顶叶可能接受认知训练干预和成功的关系学习，可以通过使用替代海马外脑区在精神分裂症中实现。
Relational learning, which is learning the relationship among items, is impaired in schizophrenia but can be improved with training. This study investigated neural changes with functional magnetic resonance imaging before and after training on a relational learning task in schizophrenia and healthy control subjects. Despite their acquiring similar relational learning performance, the groups exhibited different neural activation patterns before and following training. Controls engaged regions within the relational learning network that included frontal, parietal, and medial temporal lobe, before and following training. Controls also exhibited activation reductions in region and spatial extent with relational learning proficiency, a commonly observed phenomenon in successful learning. In contrast, subjects with schizophrenia displayed no positive activations compared with the control condition before training. After training, subjects with schizophrenia displayed bilateral inferior parietal region activation as predicted. Contrary to hypothesis, hippocampal activation was not observed following training in schizophrenia. These findings suggest that the parietal lobe may be receptive to cognitive training interventions and that successful relational learning may be achieved in schizophrenia through the use of alternative extrahippocampal brain regions.