Excretion of 3β‐hydroxy‐5‐cholenoic and 3a‐hydroxy‐5a‐cholanoic acids in urine of infants with biliary atresia
Excretion of 3β‐hydroxy‐5‐cholenoic and 3a‐hydroxy‐5a‐cholanoic acids in urine of infants with biliary atresia
复制标题
胆道闭锁婴儿尿液中 3β-羟基-5-胆烯酸和 3a-羟基-5a-胆烷酸的排泄
DOI：
10.1016/0014-5793(71)80047-9
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发表时间：
1971
期刊：
影响因子：
3.5
通讯作者：
B. Strandvik
中科院分区：
文献类型：
--
作者：
I. Makino;Jan Sjövall;A. Norman;B. Strandvik
肝外胆管闭锁的婴儿没有胆汁酸的肝肠循环。胆酸（3 α，7 α，12 α-三羟基-β-胆烷酸）和鹅去氧胆酸（3 α-二羟基-β-胆烷酸）的结合物是尿液中排泄的主要胆汁酸[1]。此外，已检测到几种具有单羟基和二羟基胆烷酸色谱特性的化合物[1]。本文报道用氧化铝层析法分离的极性较小的化合物中，主要成分为3/1-羟基-5-胆烯酸和3Cu-羟基-异胆烷酸（别石胆酸）和S-异胆烯-3/3，24+二醇。这些化合物在给予4- 14 C-胆固醇的患者样品中几乎不含或不含放射性。结果表明，在患有胆道闭锁的婴儿中形成了大量的3/1-羟基-5-胆烯酸，并且主要部分不是由用于合成胆酸和鹅去氧胆酸的胆固醇库形成的。
Infants with extrahepatic bile duct atresia have no enterohepatic circulation of bile acids. Conjugates of cholic (3a, 7a, 12a-trihydroxy-S&cholanoic) and chenodeoxycholic (3q ircr-dihydroxy-SP-cholanoic) acids are the main bile acids excreted in urine [l]. In addition, several compounds with chromatographic properties of mono-and dihydroxycholanoic acids have been detected [l]. This paper reports the identification of 3/I-hydroxy-5-cholenoic and 3cu-hydroxy-So-cholanoic (allolithocholic) acids and S-cholestene-3/3, 24&+ diol as the major components among the less polar compounds isolated by aluminum oxide chromatography. These compounds contained little or no radioactivity in samples from a patient given 4-14C-cholesterol. The results indicate that 3/I-hydroxy-5 cholenoic acid is formed in considerable amounts in infants with biliary atresia, and that the major part is not formed from the cholesterol pool used in the synthesis of cholic and chenodeoxycholic acids.