Relationship between Mediterranean Diet Score and atherothrombotic risk: Findings from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994
Relationship between Mediterranean Diet Score and atherothrombotic risk: Findings from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994
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DOI：
10.1016/j.atherosclerosis.2009.12.035
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发表时间：
2010-06-01
期刊：
影响因子：
5.3
通讯作者：
Eaton, Charles B.
中科院分区：
文献类型：
--
作者：
Carter, Stephanie J.;Roberts, Mary B.;Eaton, Charles B.
背景资料：在美国，地中海饮食已被推广为预防心血管疾病的首选饮食模式。目的：我们试图评估地中海饮食与美国人群样本中动脉粥样硬化血栓形成生物标志物水平降低的相关程度。设计：收集了13，197名年龄在18岁至90岁之间的成年人的数据，并作为NHANES III（1988-1994）的一部分评估了动脉粥样硬化血栓形成的风险因素。使用食物频率问卷评估地中海饮食的依从性，并辅以24小时饮食回忆数据，以制定地中海饮食评分（MedDietScore），并以三分位数进行分析。MedDietScore动脉粥样硬化血栓形成因素的横截面关系进行了分析，使用多变量回归分析调整复杂的抽样设计SUDAAN.Results：地中海饮食和饮食模式的协会动脉粥样硬化血栓形成的危险因素的组成部分不同的年龄和性别。对于< 45岁的男性，随着MedDietScore增加：总胆固醇/HDL胆固醇（TC/HDL）比值（p = 0.0390）、血清胰岛素（p = 0.0414）和白色血细胞（WBC）（p = 0.0246）降低。对于年龄≥ 45岁的男性，随着MedDietScore增加：TC/HDL比值（p = 0.0008）、血红蛋白A1 c（HgbA 1c）（p = 0.0001）、HOMA指数（p = 0.0486）、C反应蛋白（p = 0.0034）、纤维蛋白原（p = 0.0028）降低，HDL胆固醇（HDL-c）水平（p < 0.0001）升高。对于绝经前妇女，随着MedDietScore增加：TC/HDL比值（p < 0.0001）、非HDL胆固醇（p = 0.0012）、载脂蛋白B（p = 0.0112）、HgbA 1c（p = 0.0001）降低，HDL-c水平（p < 0.0001）升高。对于绝经后女性，随着MedDietScore增加：TC/HDL比值（p = 0.0005），甘油三酯（p < 0.0001），血清胰岛素（p = 0.0062），HOMA指数（p = 0.0063）和同型半胱氨酸（Hcy）（0.0046）水平降低，HDL-c水平（p = 0.0005）增加。地中海式饮食似乎与心脏保护性脂质谱、葡萄糖代谢、炎症和凝血水平的选择性测量相关。(c)2010爱思唯尔爱尔兰有限公司版权所有。
Background: Mediterranean diet has been promoted as the preferred dietary model for cardiovascular disease prevention in the United States.Objective: We sought to evaluate the degree to which the Mediterranean diet is associated with reduced levels of atherothrombotic biomarkers in a population-based sample in the U.S.Design: Data from 13,197 adults between the ages of 18 and 90 were collected and atherothrombotic risk factors assessed as part of the NHANES III, 1988-1994. Adherence to the Mediterranean diet was evaluated using food frequency questionnaires, supplemented by the 24-h dietary recall data, to develop Mediterranean Diet Scores (MedDietScore) that were analyzed in tertiles. The cross-sectional relationship of MedDietScore to atherothrombotic factors were analyzed using multiple variable regression analysis adjusted for complex sampling design using SUDAAN.Results: The components of the Mediterranean diet and the dietary pattern's associations with atherothrombotic risk factors differed by age and gender. For men < 45 years of age as MedDietScore increased: total cholesterol/HDL cholesterol (TC/HDL) ratio (p = 0.0390), serum insulin (p = 0.0414), and white blood cell (WBC) (p = 0.0246) decreased. For men = 45 years as MedDietScore increased: TC/HDL ratio (p = 0.0008), Hemoglobin A1c (HgbA1c) (p = 0.0001), HOMA index (p = 0.0486), C-reactive protein (p = 0.0034), fibrinogen (p = 0.0028) decreased and HDL cholesterol (HDL-c) levels (p < 0.0001) increased. For pre-menopausal women, as MedDietScore increased: TC/HDL ratio (p < 0.0001), non-HDL cholesterol (p = 0.0012), apolipoprotein B (p = 0.0112), HgbA1c (p = 0.0001), decreased and HDL-c levels (p < 0.0001) increased. For post-menopausal women, as MedDietScore increased: TC/HDL ratio (p = 0.0005), Triglycerides (p < 0.0001), serum insulin (p = 0.0062), HOMA index (p = 0.0063) and Homocysteine (Hcy) (0.0046) levels decreased and HDL-c levels (p = 0.0005) increased.Conclusions: Mediterranean diet appears to be associated with selective measures of cardioprotective lipid profiles, glucose metabolism, and inflammation and coagulation levels. (c) 2010 Elsevier Ireland Ltd. All rights reserved.