Serum cholesterol esterification in liver disease.
Serum cholesterol esterification in liver disease.
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肝脏疾病中的血清胆固醇酯化。
DOI：
10.1056/nejm197010152831604
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
R. Scheig
中科院分区：
文献类型：
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作者：
J. B. Simon;R. Scheig
摘要近年来的研究表明，血清中的卵磷脂胆固醇酰基转移酶（LCAT）可使循环中的胆固醇降低。血清对14 C-胆固醇标记的脂蛋白的能力被用来测定21例肝病患者的LCAT活性，其中大多数患者的血清胆固醇酯水平不成比例地低。14名患者的活性较低，5名患者的酯化胆固醇值低于5 μg/ml/h（对照组活性为20.4至34.1 μg/ml/h，平均值为27.6）。这种缺陷不是由于循环热稳定抑制剂或患者血清中的异常底物脂蛋白所致，而是通常与肝功能障碍的严重程度相关。患者的LCAT活性与其血清胆固醇以酯形式存在的比例之间存在直接关系（r = 0.647，p <0.001）。低LCAT活性至少可以部分解释肝病中酯化胆固醇与未酯化胆固醇的异常比例。异常是...
Abstract Recent evidence indicates that the serum enzyme lecithin-cholesterol acyltransferase (LCAT) can esterify circulating cholesterol. The ability of serum to esterify 14C-cholesterol-labeled lipoproteins was used to assay LCAT acivity in 21 patients with liver disease, most of whom had disproportionately low levels of serum cholesterol esters. Activity was low in 14 patients, five having values under 5 μg of cholesterol esterified per ml per hour (control activities 20.4 to 34.1 μg per ml per hour, with a mean of 27.6). The defect was not due to circulating heat-stable inhibitors or to abnormal substrate lipoproteins in the patients' serum, but generally paralleled the severity of hepatic dysfunction. A direct relation existed between the patients' LCAT activities and the proportion of their serum cholesterol present as esters (r = 0.647, p less than 0.001). Low LCAT activity can at least partly explain the abnormal ratio of esterified to unesterified cholesterol in liver disease. The abnormality is ...