Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man.
Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man.
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发表时间：
1981
影响因子：
6.5
通讯作者：
S. Grundy;H. Mok;L. Zech;M. Berman
中科院分区：
文献类型：
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作者：
S. Grundy;H. Mok;L. Zech;M. Berman
在 12 名高脂血症患者中研究了烟酸的降血脂作用机制。大多数患者在医院代谢病房接受研究。第一个月是对照期，随后是一个月的烟酸治疗期。在烟酸治疗期间，总血浆甘油三酯 (TG) 平均降低 52%，极低密度脂蛋白 (VLDL) 平均降低 36%。 VLDL-TG 的转运率通过注射[3H]甘油作为前体后的多室分析来确定。烟酸使 VLDL-TG 的转运（合成）平均减少 21%。 VLDL-TG 数据的动力学模型表明，TG 减少是由于 VLDL TG 含量减少，因此脂蛋白大小的减少多于数量的减少。对于整个组来说，烟酸治疗期间血浆胆固醇平均下降了 22%。该药物对胆固醇（中性类固醇）或胆汁酸的粪便排泄没有产生可检测到的变化。然而，它会引起肝脏胆汁胆固醇分泌的小幅但显着的增加，这可能导致体内胆固醇的净损失，尽管这种损失无法通过甾醇平衡检测到。尽管胆汁胆固醇的输出增加，但胆固醇摩尔％或胆囊胆汁的饱和度％没有显着增加。因此，烟酸是否会增加胆固醇胆结石的风险值得怀疑。
The mechanisms for the hypolipidemic action of nicotinic acid were examined in 12 patients with hyperlipidemia. Most patients were studied in the hospital on a metabolic ward. The first month was a control period followed by 1 month on nicotinic acid. During treatment with nicotinic acid, the triglycerides (TG) decreased in total plasma by an average of 52% and in very low density lipoproteins (VLDL) by 36%. Transport rates of VLDL-TG were determined by multicompartmental analysis following injection of [3H]glycerol as a precursor. Nicotinic acid decreased transport (synthesis) of VLDL-TG by an average of 21%. Kinetic modeling of the VLDL-TG data suggested that the TG reduction was due to a decrease in TG content of VLDL and hence a reduction in lipoprotein size more than number. For the whole group, plasma cholesterol fell during nicotinic acid therapy by a mean of 22%. The drug produced no detectable changes in fecal excretions of cholesterol (neutral steroids) or bile acids. However, it induced a small but significant increment in hepatic secretion of biliary cholesterol that might have led to a net loss of cholesterol from the body even though this loss could not be detected by sterol balance. Despite this increase in outputs of biliary cholesterol, there was not a significant increase in molar % cholesterol or in % saturation of gallbladder bile. Therefore, it is doubtful that nicotinic acid enhances the risk for cholesterol gallstones.