Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review.
Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review.
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DOI：
10.1016/j.waojou.2020.100503
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Fiocchi A
中科院分区：
文献类型：
--
作者：
Arasi S;Nurmatov U;Dunn-Galvin A;Daher S;Roberts G;Turner PJ;Shinder SB;Gupta R;Eigenmann P;Nowak-Wegrzyn A;Sánchez Borges MA;Ansotegui IJ;Fernandez-Rivas M;Petrou S;Tanno LK;Vazquez-Ortiz M;Vickery BP;Wong GW;Ebisawa M;Fiocchi A
“食物过敏”一词是指一个复杂的全球性健康问题，具有广泛的严重性。然而，目前缺乏对严重食物过敏的统一定义。这项系统性综述是对与IgE介导的食物过敏严重程度相关的当前证据进行最新概述的初步步骤;它将为临床医生和其他利益相关者达成共识以定义食物过敏严重程度的尝试提供信息。我们进行了一项混合方法的系统性综述，其中包括检索11个国际生物医学数据库，以查找从开始到2019年12月31日的已发表研究。根据预先确定的合格标准对研究进行独立筛选，并通过既定工具进行严格评价。纳入研究的实质异质性排除了荟萃分析，因此，对定量和定性数据进行了叙述性综合。我们发现23项研究提供了关于食物过敏反应的特定严重程度的合格原始数据，以及31项先前发表的食物过敏反应严重程度评分系统。有七项研究评估了不同食物过敏严重程度的患者（和家庭成员）的生活质量指标，两项研究调查了食物过敏严重程度的经济负担。总体而言，所有纳入研究的质量和总体评级均被判定为中等。在使用的严重程度评分系统之间存在异质性，甚至在食物过敏严重程度的背景下考虑结果。未验证评分。我们的研究结果将被用于为国际共识的发展提供信息，以定义食物过敏的严重程度。在国际系统性综述前瞻性登记系统（PROSPERO）数据库中前瞻性注册了一项方案，注册号为CRD 42020183103（https：//www.crd.york.ac.uk/cnio/#recordDetails）。
The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. We undertook a mixed-methods systematic review, which involved searching 11 international biomedical databases for published studies from inception to 31 December 2019. Studies were independently screened against pre-defined eligibility criteria and critically appraised by established instruments. The substantial heterogeneity of included studies precluded meta-analyses and, therefore, narrative synthesis of quantitative and qualitative data was performed. We found 23 studies providing eligible primary data on symptom-specific severity of food allergic reactions, and 31 previously published symptom-severity scoring systems referred to food allergic reactions. There were seven studies which assessed quality-of-life measures in patients (and family members) with different food allergy severity and two studies that investigated the economic burden of food allergy severity. Overall, the quality and the global rating of all included studies were judged as being moderate. There is heterogeneity among severity scoring systems used and even outcomes considered in the context of severity of food allergy. No score has been validated. Our results will be used to inform the development of an international consensus to define the severity of food allergy. A protocol was prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) database with the registration number CRD42020183103 (https://www.crd.york.ac.uk/prospero/#recordDetails).
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影响因子：
14.2
作者：
Astier, Catherine;Morisset, Martine;Kanny, Gisele
通讯作者：
Kanny, Gisele
DOI：
10.1016/j.jaip.2016.11.009
发表时间：
2017-01-01
影响因子：
9.4
作者：
Cox, Linda S.;Sanchez-Borges, Mario;Lockey, Richard F.
通讯作者：
Lockey, Richard F.
影响因子：
5.2
作者：
Braganza, SC;Acworth, JP;Brown, AFT
通讯作者：
Brown, AFT
影响因子：
14.2
作者：
Clark, S;Bock, SA;Camargo, CA
通讯作者：
Camargo, CA
影响因子：
14.2
作者：
Clark, Sunday;Wei, Wenhui;Camargo, Carlos A., Jr.
通讯作者：
Camargo, Carlos A., Jr.