Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
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DOI：
10.1016/j.jcms.2004.05.011
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发表时间：
2005-02-01
影响因子：
3.1
通讯作者：
Lee, SH
中科院分区：
文献类型：
--
作者：
Park, DJ;Choi, BH;Lee, SH
目的：几种可注射材料已被用作成骨骨替代材料。然而，没有一项得到普遍接受。本研究旨在探讨壳聚糖-藻酸盐凝胶/间充质干细胞/骨形态发生蛋白-2复合材料是否是潜在的可注射新骨形成材料。材料与方法：将复合材料植入裸鼠背部皮下，观察新骨形成情况。在12周的时间内对复合材料进行组织学检查。结果：小鼠体内注射复合材料后，可促进新骨形成，新骨形成类型为小梁型。结论：本研究表明壳聚糖-藻酸盐凝胶/MSCs/BMP-2复合材料可成为临床上可注射的成骨材料。(C)2004年欧洲颅颌面外科协会。
Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone. (C) 2004 European Association for Cranio-Maxillofacial Surgery.