Tuberculosis Infection: Insight from Immunogenomics.
Tuberculosis Infection: Insight from Immunogenomics.
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DOI：
10.1016/j.ddmec.2007.11.003
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Hawn, Thomas R
中科院分区：
文献类型：
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作者：
Arentz, Matthew;Hawn, Thomas R
结核病仍然是导致发病率和死亡率的最重要的全球传染病原因之一。开发更有效的疫苗是世界范围内的高度优先事项，取决于对宿主对感染的反应的彻底了解。在这篇综述中，我们重点介绍了我们对结核分枝杆菌感染的先天免疫反应的理解的最新进展。我们还描述了免疫遗传学的最新发现，这些发现有助于深入了解免疫调节疗法的潜在发展。
Tuberculosis continues to be one of the most important global infectious causes of morbidity and mortality. Development of a more effective vaccine is a high worldwide priority and depends on a thorough understanding of the host response to infection. In this review, we highlight recent advances in our understanding of the innate immune response to MTb infection. We also describe recent discoveries in immunogenetics that are generating insight into the potential development of immunomodulatory therapies.