Measuring venous blood volume changes during activation using hyperoxia
Measuring venous blood volume changes during activation using hyperoxia
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DOI：
10.1016/j.neuroimage.2011.11.041
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发表时间：
2012-02-15
期刊：
影响因子：
5.7
通讯作者：
Gowland, P. A.
中科院分区：
文献类型：
--
作者：
Blockley, N. P.;Driver, I. D.;Gowland, P. A.
本研究描述了一种新的方法，用于测量静脉脑血容量（CBVv）的相对变化，使用高氧作为造影剂。该方法利用血管外BOLD效应及其对任务相关激活诱导的静脉血氧合变化和由于呼吸富氧气体混合物引起的变化的依赖性。激活时CBVv的变化可以通过比较横向弛豫速率的变化来估计。R-2（*），由于基线和激活状态下的高氧。此外，这些测量值可以转换为CBVv百分比变化的测量值。进行实验以测量响应于简单运动任务的CBVv加权信号的变化。CBVv加权信号的正性和负性变化均见于BOLD阳性激活区。(C)2011 Elsevier Inc. All rights reserved.
This study describes a novel method for measuring relative changes in venous cerebral blood volume (CBVv) using hyperoxia as a contrast agent. This method exploits the extravascular BOLD effect and its dependency on both task-related activation induced changes in venous blood oxygenation and changes due to breathing an oxygen enriched gas mixture. Changes in CBVv on activation can be estimated by comparing the change in transverse relaxation rate. R-2(*), due to hyperoxia in both baseline and activation states. Furthermore these measurements can be converted into a measure of the percentage change in CBVv. Experiments were performed to measure changes in a CBVv-weighted signal in response to a simple motor task. Both positive and negative changes in CBVv-weighted signal were detected in the positively activated BOLD region. (C) 2011 Elsevier Inc. All rights reserved.