CYCLOSPORIN-A INHIBITS THE GROWTH OF CRYPTOCOCCUS-NEOFORMANS IN A MURINE MODEL
CYCLOSPORIN-A INHIBITS THE GROWTH OF CRYPTOCOCCUS-NEOFORMANS IN A MURINE MODEL
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DOI：
10.1128/iai.56.1.7-12.1988
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发表时间：
1988-01-01
影响因子：
3.1
通讯作者：
LIPSCOMB, MF
中科院分区：
文献类型：
--
作者：
MODY, CH;TOEWS, GB;LIPSCOMB, MF
新型隐球菌是一种常见的机会性感染病原体，在患者T淋巴细胞介导的免疫功能下降，包括那些与获得性免疫缺陷综合征。为研究C.在T细胞功能受损的情况下的新生儿感染。令人惊讶的是，在接受免疫抑制剂量的CsA的动物中，无论是气管内还是静脉内接种C.新人类此外，经腹腔接种后，CsA处理的小鼠清除了C。比对照组小鼠更快地从肺部排出。CsA直接抑制C.当其以与实验小鼠中达到的血液水平相当的浓度添加到体外培养物中时，因此，CsA在体外和体内均能抑制C.新人类虽然这些结果必须扩展到人类的研究，这些数据表明，现在接受CsA免疫抑制治疗的患者可能会意外地免受C。新人类此外，对环孢菌素衍生物的研究可能产生具有较低免疫抑制特性的化合物，增强抗真菌活性。
Cryptococcus neoformans is a frequent opportunistic infectious agent in patients with decreased T-lymphocyte-mediated immune function, including those with acquired immune deficiency syndrome. Cyclosporin A (CsA), a potent inhibitor of T-lymphocyte function, was administered subcutaneously to mice to study the pathogenesis of C. neoformans infections in the setting of impaired T-cell function. Surprisingly, survival was prolonged indefinitely in animals that received immunosuppressive doses of CsA following either intratracheal or intravenous inoculations of C. neoformans. Furthermore, following intratracheal inoculation, mice treated with CsA cleared C. neoformans from their lungs more rapidly than did control mice. CsA directly inhibited the growth of C. neoformans when it was added to cultures in vitro at concentrations comparable to the blood levels achieved in experimental mice. Thus, CsA inhibited both in vitro and in vivo growth of C. neoformans. While these results must be extended to studies in humans, these data suggest that patients who now receive CsA-immunosuppressive therapy may be fortuitously protected against infections with C. neoformans. Furthermore, research into cyclosporin derivatives may yield compounds with less immunosuppressive properties are enhanced antifungal activity.