Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer
Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer
复制标题
DOI：
10.1002/adma.200600385
复制
发表时间：
2006-10-04
影响因子：
29.4
通讯作者：
Gao, Mingyuan
中科院分区：
文献类型：
--
作者：
Hu, Fengqin;Wei, Li;Gao, Mingyuan
具有生物相容性的Fe3O4磁性纳米晶体，其表面具有反应性部分，可以通过“一锅法”反应制备，并通过与特异性癌症靶向抗体偶联直接用于癌症检测。结果表明，所制备的Fe3O4纳米晶体可以潜在地用作有效的磁共振成像（MRI）造影剂，用于癌症诊断（见图）。
Biocompatible Fe3O4 magnetic nanocrystals with reactive moieties on the surface can be prepared via a "one-pot" reaction and used straightforwardly in cancer detection by being coupled with a specific cancer-targeting antibody. It is demonstrated that the as-prepared Fe3O4 nanocrystals can potentially be used as effective magnetic resonance imaging (MRI) contrast agents for cancer diagnosis (see figure).