Effect in the conscious dog of constriction of the renal artery to a sole remaining kidney on haemodynamics, sodium balance, body fluid volumes, plasma renin concentration and pressor responsiveness to angiotensin.
Effect in the conscious dog of constriction of the renal artery to a sole remaining kidney on haemodynamics, sodium balance, body fluid volumes, plasma renin concentration and pressor responsiveness to angiotensin.
复制标题
在清醒的狗中，肾动脉收缩到唯一剩余的肾脏对血流动力学、钠平衡、体液容量、血浆肾素浓度和对血管紧张素的升压反应性的影响。
DOI：
10.1042/cs0380741
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发表时间：
1970
期刊：
影响因子：
6
通讯作者：
R. Lucca
中科院分区：
文献类型：
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作者：
Giuseppe Bianchi;L. Tenconi;R. Lucca
1.在14只清醒的狗中，对一个单独的剩余肾脏的肾动脉进行了收缩。测量所有动物的以下变量：血压（BP）、心率（CR）、血浆肾素浓度（PRC）、血浆容量（PV）、细胞外液容量（ECFV）和血浆非蛋白氮（NPN）。估计了11只犬的钠平衡。本文测定了9条犬的心输出量（CO）、总外周阻力（TPR）和每搏输出量（SV）。在6只动物中测定血管紧张素反应性（AR）。2.在2小时内发生以下变化：BP，PRC和TPR急剧增加，CO和CR最初减少或无变化; SV和PV无变化。BP变化对PRC变化的线性回归与先前在清醒犬中输注外源性肾素期间获得的线性回归没有统计学差异。AR在2小时时非常沮丧。24小时后出现轻微但显著的钠潴留，PV、ECFV和SV增加，CO由于CR降低而保持不变。PRC趋于恢复正常，而BP仍然很高。因此，这两个变量之间的线性回归消失。在这个阶段，AR增加到正常水平，两只犬超过正常水平。4.缩窄后3-4和6-7天，CO因SV升高而升高，TPR下降。扩大PV和ECFV，同时维持钠平衡。AR在个体犬中变化很大，主要取决于PRC、钠平衡和PV的变化。5.在第12-14天，钠平衡再次变为阳性，几乎所有犬的PRC均恢复至正常水平。PV和ECFV也趋于下降至正常。在此阶段仅在两只犬中测量CO和AR。6.结果提示，早期血压升高可能是由PRC升高引起的，而收缩后3-6天，PV扩张，CO升高，有助于维持高血压。
1. The renal artery to a lone remaining kidney was constricted in fourteen concious dogs. The following variables were measured in all animals: blood pressure (BP), cardiac rate (CR), plasma renin concentration (PRC), plasma volume (PV), extracellular fluid volume (ECFV) and plasma non-protein nitrogen (NPN). Sodium balance was estimated in eleven dogs. Cardiac output (CO), total peripheral resistence (TPR) and stroke volume (SV) were measured in nine dogs. Angiotensin responsiveness (AR) was measured in six animals. 2. Within 2 hr the following changes occurred: a sharp increment of BP, PRC and TPR, with initial reduction or no change in CO and CR; SV and PV were not changed. The linear regression of BP changes on PRC changes did not differ statistically from the one previously obtained during the infusion of exogenous renin in the conscious dog. AR was much depressed at 2 hr. 3. After 24 hr a slight but significant sodium retention developed, while PV and ECFV and SV increased, CO remained unchanged owing to a decrease of CR. PRC tended to return toward normal while BP remained high. Thus the linear regression between these two variables disappeared. At this stage AR increased toward normal and in two dogs exceeded normal. 4. On days 3–4 and 6–7 after constriction, CO increased owing to a rise of SV, while TPR decreased. PV and ECFV were expanded while sodium balance was maintained. AR varied very much in the individual dogs according mainly to changes of PRC, sodium balance and PV. 5. On days 12–14 sodium balance became positive again, PRC returned within normal levels in almost all the dogs. PV and ECFV also tended to decrease to normal. CO and AR were measured in only two dogs at this stage. 6. It is suggested that the early rise of blood pressure might be produced by the increase of PRC, while 3–6 days after the constriction the expansion of PV with the increase of CO contributed to the maintenance of the hypertension.