Effects of frictional losses and pulsatile flow on the collapse of stenotic arteries
Effects of frictional losses and pulsatile flow on the collapse of stenotic arteries
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DOI：
10.1115/1.2796096
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发表时间：
1997-08-01
影响因子：
1.7
通讯作者：
Ku, DN
中科院分区：
文献类型：
--
作者：
Downing, JM;Ku, DN
高度狭窄会导致动脉塌陷。顺应性狭窄的一维数值模型是根据夏皮罗的可折叠管理论开发的。该模型通过考虑摩擦损失和不稳定的影响来扩展早期模型。该模型用于研究体内环境中存在的几个物理参数的相对重要性。结果表明狭窄内可能发生塌陷。摩擦损失对降低塌陷程度有影响。即使下游阻力较低，较大的分离损失也可以防止彻底崩溃。然而，狭窄程度仍然是控制塌陷发生的主要参数。脉动溶液证明了在狭窄内产生循环塌陷的条件。这项研究预测了某些生理条件下，高度狭窄可能会发生动脉塌陷。
High-grade stenosis can produce conditions in which the artery may collapse. A one-dimensional numerical model of a compliant stenosis was developed from the collapsible tube theory of Shapiro. The model extends an earlier model by including the effects of frictional losses and unsteadiness. The model was used to investigate the relative importance of several physical parameters present in the in vivo environment. The results indicated that collapse can occur within the stenosis. Frictional loss was influential in reducing the magnitude of collapse. Large separation losses could prevent collapse outright even with low downstream resistances. However, the degree of stenosis was still the primary parameter governing the onset of collapse. Pulsatile solutions demonstrated conditions that produce cyclic collapse within the stenosis. This study predicts certain physiologic conditions in which collapse of arteries may occur for high-grade stenoses.