Association between exhaled nitric oxide, ambient air pollution and respiratory health in school children
Association between exhaled nitric oxide, ambient air pollution and respiratory health in school children
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DOI：
10.1007/s00420-002-0320-x
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发表时间：
2002-06-01
影响因子：
3
通讯作者：
van Amsterdam, JGC
中科院分区：
文献类型：
--
作者：
Fischer, PH;Steerenberg, PA;van Amsterdam, JGC
目的：本研究的目的是探讨呼出一氧化氮 (eNO) 水平是否比传统肺功能指数更能提供更灵敏的指标来评估空气污染对肺部的不利影响。方法：研究的非选定队列由 68 名生活在城市环境中的儿童（10-11 岁）组成。在 7 周的时间里，这些孩子每天在日记中报告呼吸道疾病，并在不同空气污染程度的日子里每周一次测定孩子们的肺功能指标和 eNO 水平。结果：研究期间，各种空气污染物水平的增加与 eNO 呈正相关（增加 6% 至 31%；P < 0.05），但与肺功能指标无关。与肺功能测量相比，“喉咙痛”、“鼻黄”、“感冒”和“在家生病”等呼吸道症状的发生率与接下来一周测量的 eNO 水平呈正相关。结论：尽管在临床上非常有意义，但功能性肺部测量似乎过于简单，无法检测暴露于空气污染后相对轻微的临床症状。在流行病学背景下，eNO 的增加可能是评估此类不良反应的更合适的衡量标准。
Objectives: The aim of the study was to investigate whether the level of exhaled nitric oxide (eNO) provides a more sensitive measure to assess adverse pulmonary effects of air pollution than conventional lung function indices. Method: The non-selected cohort studied consisted of 68 children (aged 10-11 years) living in an urban environment. For 7 weeks respiratory complaints were reported daily by these children in a diary, and lung function measures and eNO levels were determined in the children once a week on days with various level of air pollution. Results: During the study the increase in the levels of the various air pollutants was positively associated with eNO (6% to 31% increase; P < 0.05) but not with lung function measures. In contrast to the lung function measures, the prevalence of respiratory symptoms such as "sore throat", "rutiny nose", "having a cold", and "sick at home" were positively associated with the level of eNO measured in the following week. Conclusions: Though clinically very meaningful, functional pulmonary measures appear to be too course to detect relatively mild clinical symptoms in response to exposure to air pollution. In an epidemiological setting the increase in eNO may represent a more suitable measure to assess such adverse effects.