EVIDENCE FOR A REACTION-DIFFUSION SYSTEM AS A MECHANISM CONTROLLING MAMMALIAN HAIR-GROWTH
EVIDENCE FOR A REACTION-DIFFUSION SYSTEM AS A MECHANISM CONTROLLING MAMMALIAN HAIR-GROWTH
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DOI：
10.1016/0303-2647(83)90015-1
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发表时间：
1983-01-01
期刊：
影响因子：
1.6
通讯作者：
NAGORCKA, BN
中科院分区：
文献类型：
--
作者：
NAGORCKA, BN
本文概述了毛囊鳞茎上皮细胞的分化方案，该方案需要反应扩散系统的几个空间模式特性。在反应和扩散的物质中，称为形态原的空间模式，根据毛囊球的大小和形状自发地形成。这些模式正确地预测了老鼠体内几种纤维的横截面形状，这些纤维被称为锥子纤维、奥氏纤维和之字形纤维。空间模式也决定了纤维横截面内正皮层细胞和皮层旁细胞的分布。为了解释所观察到的之字形纤维形态的变化，有必要利用反应扩散系统的能力来产生具有首选取向的空间图案。将毛囊球的真皮乳头移离中心会导致形态形成的均匀模式变得不稳定，并导致双侧模式以首选方向发展。这种现象构成了控制之字形纤维形成机制的基础。
A scheme is outlined for the differentiation of epithelial cells in hair follicle bulbs which requires several spatial pattern properties characteristic of a reaction-diffusion system. Spatial patterns in the reacting and diffusing substances, called morphogens, develop spontaneously depending on the size and shape of the follicle bulb. The patterns correctly predict the cross-sectional shape of several classes of fibers known as awls, auchenes and zigzags found in mice. The spatial patterns also determine the distribution of ortho- and para-cortical cells within the fiber cross-section. In order to explain the observed variation in the morphology of zigzag fibers it is necessary to use the capacity of a reaction-diffusion system to produce spatial patterns with a preferred orientation. Moving the dermal papilla of the hair follicle bulb off-center causes a homogeneous pattern of morphogens to become unstable and a bilateral pattern to develop with a preferred orientation. This phenomenon forms the basis of a control mechanism for the formation of zigzag fibers.