Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers.
Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers.
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DOI：
10.1021/acs.orglett.5b01463
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发表时间：
2015-07-02
期刊：
影响因子：
5.2
通讯作者：
Molander GA
中科院分区：
文献类型：
--
作者：
Karakaya I;Primer DN;Molander GA
单电子金属转移已经成为Csp 3杂化的有机三氟硼酸酯的交叉偶联的一个使能范例。通过使用铱光氧化还原催化剂和Ni交叉偶联催化剂的组合的双重催化，已经证明了α-烷氧基甲基三氟硼酸酯与芳基和杂芳基溴的交叉偶联。所得到的方法能够在温和的室温条件下对不同的（杂）芳烃进行烷氧基甲基化。
Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of Csp3 hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions.