EFFECTS OF A SINGLE POSTOVULATORY DOSE OF RU486 ON ENDOMETRIAL MATURATION IN THE IMPLANTATION PHASE
EFFECTS OF A SINGLE POSTOVULATORY DOSE OF RU486 ON ENDOMETRIAL MATURATION IN THE IMPLANTATION PHASE
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DOI：
10.1093/oxfordjournals.humrep.a138458
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发表时间：
1994-12-01
影响因子：
6.1
通讯作者：
BYGDEMAN, M
中科院分区：
文献类型：
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作者：
GEMZELLDANIELSSON, K;SVALANDER, P;BYGDEMAN, M
在着床期研究了排卵后单剂量RU 486对子宫内膜成熟的影响。共有11名健康女性接受了一个对照和一个或两个治疗周期的随访。在治疗周期中，在促黄体激素（LH）+2天给予200或400 mg RU 486的剂量。在对照和治疗周期中，在LH+6至1，11 +8获得子宫内膜活检。这些活检进行了评估，形态计量学和免疫组化分析。用RU 486处理不干扰正常的月经节律，但引起子宫内膜发育的显著抑制。在RU 486处理后，腺体孕酮受体染色显著更明显，而双花扁豆凝集素凝集素结合减少，表明子宫内膜的正常分泌转化受到抑制。这些对子宫内膜发育和分泌活性的影响可能是排卵后RU 486治疗避孕作用的基础。
The effect of a single post-ovulatory dose of RU486 on endometrial maturation was studied in the implantation phase. A total of 11 healthy women were followed for one control and one or two treatment cycles. In treatment cycles, a dose of 200 or 400 mg RU486 was administered on day luteinizing hormone (LH)+2. In both control and treatment cycles, an endometrial biopsy was obtained on LH+6 to 1,11+8. These biopsies were assessed by morphometric and immunohistochemical analyses. The treatment with RU486 did not disturb the normal menstrual rhythm but caused a significant inhibition in the endometrial development, Glandular progesterone receptor staining was significantly more pronounced after RU486 treatment, while there was a reduction in the Dolichos biflorus agglutinin lectin binding, indicating inhibition of the normal secretory transformation of the endometrium. It is likely that these effects on endometrial development and secretory activity represent the basis of the contraceptive effect of post-ovulatory RU486 treatment.