Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men
Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men
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DOI：
10.1038/sj.ijo.0803003
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发表时间：
2005-09-01
影响因子：
4.9
通讯作者：
Babb, TG
中科院分区：
文献类型：
--
作者：
DeLorey, DS;Wyrick, BL;Babb, TG
目的：探讨轻度至中度肥胖对肥胖男性休息和运动时呼吸力学的影响。我们假设肥胖的简单质量负荷会改变静息体位和分级周期测量至衰竭时的呼气末肺体积（EELV）和呼吸压力（胃、Pga和跨肺、P-TP）。研究对象：共有10名肥胖男性（38 +/- 5%体脂，平均+/- s.d）和9名瘦男性（1874%）被研究。方法：静息时测定体组成（体围和静水称重法）和肺功能。呼吸力学分别在直立坐姿、仰卧位和骑自行车运动时测量。数据分析采用独立t检验。结果：肥胖男性在仰卧位（30 +/- 4 vs 37 +/- 6%总肺容量（TLC））、坐位（3976 vs 47 +/- 5% TLC）和通气阈值（35 +/- 5 vs 45 +/- 7% TLC）时的EELV显著降低（P < 0.01）。相反，在运动高峰时，各组之间的EELV没有差异。肥胖男性在休息和运动时呼吸循环的一个或多个阶段呼吸压（Pga和PTP）升高（P < 0.05）。结论：这些数据表明，年轻男性轻度至中度肥胖会导致仰卧、坐着休息和运动时肺容量减少和呼吸力学改变。在适度运动期间，肥胖似乎不会限制EELV的变化；然而，在剧烈运动期间，EELV的调节似乎受到了影响。
OBJECTIVE: To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men. We hypothesized that the simple mass loading of obesity would alter both end-expiratory lung volume (EELV) and respiratory pressures (gastric, Pga and transpulmonary, P-TP) in resting body positions and during graded cycle ergometry to exhaustion.SUBJECTS: A total of 10 obese (38 +/- 5% body fat; mean +/- s.d.) and nine lean (1874%) men were studied.METHODS: Body composition (by body circumferences and hydrostatic weighing) and pulmonary function were measured at rest. Breathing mechanics were measured at rest in the upright-seated position, supine, and during cycling exercise. Data were analyzed by independent t-test.RESULTS: EELV was significantly lower in the obese men in the supine (30 +/- 4 vs 37 +/- 6% total lung capacity (TLC)) and seated (3976 vs 47 +/- 5% TLC) positions and at ventilatory threshold (35 +/- 5 vs 45 +/- 7% TLC) (P < 0.01). In contrast, at peak exercise, EELV was not different between groups. Respiratory pressures (Pga and PTP) were elevated (P < 0.05) during one or more phases of the breathing cycle at rest and during exercise in obese men.CONCLUSION: These data demonstrate that mild- to-moderate obesity in young men results in reduced lung volumes and alterations in respiratory mechanics when supine, seated at rest, and during exercise. During moderate exercise, obesity does not appear to limit changes in EELV; however, the regulation of EELV during heavy exercise appears to be affected.