The Ninth Sir Hans Krebs Lecture. Compartmentation and communication in living systems. Ligand conduction: a general catalytic principle in chemical, osmotic and chemiosmotic reaction systems.
The Ninth Sir Hans Krebs Lecture. Compartmentation and communication in living systems. Ligand conduction: a general catalytic principle in chemical, osmotic and chemiosmotic reaction systems.
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第九届汉斯·克雷布斯爵士讲座。
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发表时间：
1979
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通讯作者：
P. Mitchell
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作者：
P. Mitchell
化学反应，像渗透反应一样，如果仔细看的话，也是一种输运过程。酶或催化载体的化学催化作用，以及转运蛋白的渗透催化作用，可以被认为是通过特定的配体传导机制发生的。在化学渗透反应系统中，特定配体传导的途径通过各向异性酶和催化载体复合物在空间上定向，其中化学基团转移的反应作为基团移位的矢量扩散过程沿基团势梯度发生，基团势梯度代表真实的空间定向的化学力场。因此，用运输来解释生物化学要比用生物化学来解释运输容易得多。
Chemical reactions, like osmotic reactions, are transport processes when looked at in detail. Chemical catalysis by enzymes or catalytic carriers, and osmotic catalysis by porters, may be conceived as occurring by specific ligand-conduction mechanisms. In chemiosmotic reaction systems, the pathways of specific ligand conduction are spatially orientated through anisotropic enzyme and catalytic carrier complexes in which the reactions of chemical group transfer occur as vectorial diffusion processes of group translocation down gradients of group potential that represent real spatially-directed fields of chemical force. Thus, it is easier to explain biochemistry in terms of transport than it is to explain transport in terms of biochemistry.