THE NEOSTRIATAL MOSAIC .1. COMPARTMENTAL ORGANIZATION OF PROJECTIONS FROM THE STRIATUM TO THE SUBSTANTIA NIGRA IN THE RAT
THE NEOSTRIATAL MOSAIC .1. COMPARTMENTAL ORGANIZATION OF PROJECTIONS FROM THE STRIATUM TO THE SUBSTANTIA NIGRA IN THE RAT
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DOI：
10.1002/cne.902360404
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
GERFEN, CR
中科院分区：
文献类型：
--
作者：
GERFEN, CR
应用神经解剖学方法研究了大鼠纹状体向黑质投射的组织结构。采用双向顺行轴突追踪法（Phaseolusvulgaris leuco-agglutinin，PHA-L）和3 H-氨基酸束追踪法（3 H-amino acid tract tracking）和双向荧光逆行轴突运输追踪法（double fluorescent retrograde axonal transport tracking），研究了投射到黑质不同区域的纹状体神经元之间的相互关系。此外，逆行标记的纹状体黑质投射神经元的分布绘制相对于神经化学上不同的纹状体补丁隔室，确定P物质或亮氨酸脑啡肽样免疫反应，并相对于互补的基质隔室，确定生长抑素样免疫反应纤维。这些研究显示了纹黑质投射中的两种不同类型的组织。一种类型是地形，这些纹状体传出神经元之间的中侧关系大致维持其终止模式在黑质，而背腹侧的关系是颠倒的。然而，来自纹状体任何部分的投射都分布在黑质的吻尾轴上。尽管他们的一般地形组织，变量和分散的性质，这样的预测从个别纹状体位点的结果在部分重叠的传入领域从单独的纹状体区。第二种组织类型是非地形性的，它为叠加在粗糙地形系统上的来自分离纹状体区的输入的会聚提供了一个不同的系统。在这另一种投射系统中，拓扑有序系统中典型的内外侧和背腹侧关系没有得到维持，有时甚至相反。这些结果表明，纹状体补丁和基质室提供隔离的平行输入输出途径，通过内在纹状体神经元本地连接。这种模块化组织在整个纹状体中重复，用于基底神经节对皮质输入的整合处理。
Combined neuroanatomical techniques were used to examine the organization of the striatal projection to the substantia nigra in the rat. Both double anterograde axonal tracing methods (Phaseolus vulgaris leuco-agglutinin (PHA-L) and 3H-amino acid tract tracing) and double fluorescent retrograde axonal transport tracing methods were used to examine the relationship among striatal neurons projecting to separate areas of the substantia nigra. Additionally, the distributions of retrogradely labeled striatonigral projection neurons were charted relative to the neurochemically distinct striatal patch compartment, identified by substance P- or leu-enkephalin-like immunoreactivity, and relative to the complementary matrix compartment, identified by somatostatin-like immunoreactive fibers. These studies show 2 distinct types of organization in the striatonigral projections. One type is topographic in that the mediolateral relationships among these striatal efferent neurons are roughly maintained by their termination patterns in the substantia nigra, while the dorsoventral relationships are inverted. Projections from any part of the striatum, however, are distributed throughout the rostrocaudal axis of the substantia nigra. Despite their general topographic organization, the variable and dispersed nature of such projections from individual striatal loci results in partial overlap of afferent fields from separate striatal areas. The 2nd type of organization is nontopographic, and it provides a different system for convergence of imputs from separated striatal areas that is superimposed on the rough topographic system. In this other projection system, the mediolateral and dorsoventral relationships typical of the topographically ordered system are not maintained, and are sometimes reversed. These results suggest that the striatal patch and matrix compartments provide segregated parallel input-output pathways that are linked locally via intrinsic striatal neurons. This modular organization is reiterated throughout the striatum for integrative processing of cortical inputs by the basal ganglia.