Cannabidiol and tetrahydrocannabinol concentrations in commercially available CBD E-liquids in Switzerland
Cannabidiol and tetrahydrocannabinol concentrations in commercially available CBD E-liquids in Switzerland
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DOI：
10.1016/j.forsciint.2020.110261
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发表时间：
2020-05-01
影响因子：
2.2
通讯作者：
Weinmann, Wolfgang
中科院分区：
文献类型：
--
作者：
Grafinger, Katharina Elisabeth;Kronert, Severine;Weinmann, Wolfgang
富含大麻二酚（CBD）的大麻和Delta（9）-四氢大麻酚（THC）含量低（低于1%）的大麻产品在瑞士合法供应。除了用于吸烟的草药和油之外，最近市场上还出现了用于在电子烟（e-cigs）中吸烟的液体（e-liquid）。这些电子液体具有不同的CBD浓度，并且可以调味。目前研究的目的是调查在瑞士合法获得的20种电子液体的含量，使用傅里叶变换红外光谱（FTIR）作为初步步骤，然后进行气相色谱-质谱联用，以识别潜在的大麻素，天然植物化合物和香料。CBD，大麻二酚羧酸（CBD-酸）的定量。通过具有偶联至二极管阵列检测器的超高压-液相色谱法（UHPLC-DAD）的经验证的方法进行大麻酚（CBN）、Δ（9）-四氢大麻酚（THC）和Δ（9）-四氢大麻酚羧酸A（THC-酸）的分析FTIR分析可以证实，对于所有研究的样品，电子液体基质由1，2-丙二醇和甘油组成。定性GC-MS可鉴定出10种植物大麻素，包括定量分析物、6种天然植物化合物和5种香料。所有分析样品的THC总含量均低于0.1059%（以重量计），符合瑞士和加拿大的法律的要求（
Cannabidiol (CBD) rich hemp and hemp products low in Delta(9)-tetrahydrocannabinol (THC) (less than 1%) are legally available in Switzerland. Besides herbs for smoking and oils, liquids (e-liquids) for smoking in electronic cigarettes (e-cigs) have recently appeared on the market. These e-liquids are available with different CBD concentrations and can be flavoured. The aim of the current study was to investigate 20 e-liquids legally available in Switzerland for their contents using Fourier-transform infrared spectroscopy (FTIR) as a preliminary step followed by gas-chromatography coupled to mass spectrometry to identify potential cannabinoids, natural plant compounds and flavours. Quantification of CBD, cannabidiol carboxylic acid (CBD-acid). cannabinol (CBN), Delta(9)-tetrahydrocannabinol (THC), and Delta(9)-tetrahydrocannabinol carboxylic acid A (THC-acid) was performed by a validated method with ultra-high-pressure-liquid chromatography coupled to a diode array detector (UHPLC-DAD).FTIR analysis could confirm that for all investigated samples the e-liquid matrix consisted of 1,2-propanediol and glycerol. The qualitative GC-MS could identify ten phytocannabinoids including the quantified analytes, six natural plant compounds and five flavours.All analysed samples had a total THC content below 0.1059% (by weight), hence meeting the legal requirements of both Switzerland (