Local wavefront mapping in tissue using computational adaptive optics OCT.
Local wavefront mapping in tissue using computational adaptive optics OCT.
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DOI：
10.1364/ol.44.001186
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发表时间：
2019-03
期刊：
影响因子：
3.6
通讯作者：
F. South;Y. Liu;Pin-Chieh Huang;Tabea Kohlfarber;S. Boppart
中科院分区：
文献类型：
--
作者：
F. South;Y. Liu;Pin-Chieh Huang;Tabea Kohlfarber;S. Boppart
波前像差的识别和校正对于实现生物组织的高分辨率光学图像通常是必要的，因为光学系统和组织本身的缺陷使成像光束失真。测量局部波前像差提供了关于光束在何处畸变以及畸变程度的信息。我们最近开发了一种方法来估计单程波前像差从复杂的光学相干层析成像（OCT）数据。使用该方法，在离体组织中使用计算OCT进行局部波前测量和校正。计算测量的波前在整个成像OCT体积中变化，因此，局部波前校正优于全局波前校正。局部波前测量也用于生成组织像差图。这样的像差图可以潜在地用作组织对比的新形式。
The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.