Cocaine sensitization increases kyphosis and modulates neural activity in adult nulliparous rats.
Cocaine sensitization increases kyphosis and modulates neural activity in adult nulliparous rats.
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DOI：
10.3390/brainsci2040667
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发表时间：
2012-11-27
期刊：
影响因子：
3.3
通讯作者：
Febo M
中科院分区：
文献类型：
--
作者：
Nephew BC;Caffrey MK;Felix-Ortiz AC;Febo M
虽然来自动物和人类的数据表明，成年人使用可卡因可能对行为产生长期影响，但尚不清楚既往使用可卡因是否会影响未生育女性未来的母性行为。在本研究中，将可卡因或生理盐水给予成年雌性大鼠10天，将动物从可卡因中戒断7天，然后将雌性大鼠暴露于供体幼仔以诱导母性行为的表达。对可卡因敏感的未产雌性动物更有可能取回幼崽，花更多的时间照顾幼崽，并且在幼崽暴露的第8天更有可能表达完整的母性行为。fMRI数据显示，海马CA1区的幼鼠暴露的显着影响，以及前丘脑和导水管周围灰质的可卡因的影响。先前成年人使用可卡因可能对后代护理产生持久影响，这种影响不依赖于幼犬介导的影响或妊娠和哺乳期的内分泌变化。目前的研究结果提供了支持的假设，即母亲的动机，表现出母性的行为是增强了先前的可卡因敏化，可能是由于可卡因和母性行为的自然奖励之间的交叉敏化。
Although data from both animals and humans suggests that adult cocaine use can have long term effects on behavior, it is unknown if prior cocaine use affects future maternal behavior in nulliparous females. In the current study, cocaine or saline was administered to adult female rats for 10 days, the animals were withdrawn from cocaine for 7 days, and the females were then exposed to donor pups to induce the expression of maternal behavior. Nulliparous females sensitized to cocaine were more likely to retrieve pups, spent more time caring for the pups, and were more likely to express full maternal behavior on day 8 of pup exposure. The fMRI data revealed significant effects of pup exposure in the hippocampal CA1 region, and effects of cocaine in the anterior thalamus and periaqueductal gray. Prior adult cocaine use may have lasting effects on offspring care, and this effect is not dependent on pup mediated effects or the endocrine changes of gestation and lactation. The present findings provide support for the hypothesis that maternal motivation to exhibit maternal behavior is enhanced by prior cocaine sensitization, possibly due to cross sensitization between cocaine and the natural reward of maternal behavior.