New insights into plasticity of pancreatic cancer: cancer to acinar cell reprogramming by the basic helix-loop-helix transcription factor E47.
New insights into plasticity of pancreatic cancer: cancer to acinar cell reprogramming by the basic helix-loop-helix transcription factor E47.
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对胰腺癌可塑性的新见解：通过基本螺旋-环-螺旋转录因子 E47 将癌症转化为腺泡细胞。
DOI：
10.1097/mpa.0000000000000374
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发表时间：
2015
期刊：
影响因子：
2.9
通讯作者：
Maitra,Anirban
中科院分区：
文献类型：
--
作者：
Bailey,JenniferM;Hendley,AudreyM;Maitra,Anirban
预计到2020年，胰腺导管腺癌（PDAC）将成为美国癌症相关死亡的第二大常见原因。目前PDAC的治疗方法仍然有限，部分原因是与这种疾病相关的广泛的遗传和细胞异质性。PDAC最有效的治疗方法仍然是手术切除，但这种选择仅适用于20%的可切除疾病患者。即使在成功切除后，PDAC在80%的患者中复发。1早期检测方法是一个重点研究领域，以改善诊断为PDAC的患者的治疗选择。
Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second most common cause of cancer-related deaths in the United States by 2020. Current treatment methods for PDAC remain limited in part because of the extensive genetic and cellular heterogeneity associated with this disease. The most effective treatment for PDAC remains surgical resection, but this option is only available to 20% of patients who present with resectable disease. Even after successful resection, PDAC recurs in 80% of patients. 1 Early detection methods are one focused area of investigation to improve therapeutic options for patients' condition diagnosed with PDAC.