Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy.
Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy.
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DOI：
10.1097/qad.0000000000003319
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发表时间：
2022-11-15
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中科院分区：
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尽管在暴露前预防方面取得了进展，但新诊断出的 HIV-1 病例数量仍然很高，这突出表明迫切需要采取预防和治疗策略来减少 HIV-1 感染并限制疾病进展。急性感染期间发生的早期免疫事件是疾病结果和病程的关键决定因素。了解病毒设定点建立之前发生的早期免疫反应对于确定预防和治疗方法的潜在目标至关重要。自然杀伤 (NK) 细胞是先天免疫的关键细胞组成部分，有助于宿主早期防御 HIV-1 感染，调节急性 HIV-1 感染 (AHI) 的发病机制。新兴研究已经确定了利用 NK 细胞反应和扩大具有适应性/记忆功能的专门 NK 亚群的工具，为新型 HIV-1 疗法的开发铺平了道路。这篇综述重点介绍了 NK 细胞亚群在遏制急性 HIV-1 感染中的作用的已知和未知，并总结了通过预防和治疗干预选择性增强 NK 细胞功能的最新进展。
Despite progress in preexposure prophylaxis, the number of newly diagnosed cases with HIV-1 remains high, highlighting the urgent need for preventive and therapeutic strategies to reduce HIV-1 acquisition and limit disease progression. Early immunological events, occurring during acute infection, are key determinants of the outcome and course of disease. Understanding early immune responses occurring before viral set-point is established, is critical to identify potential targets for prophylactic and therapeutic approaches. Natural killer (NK) cells represent a key cellular component of innate immunity and contribute to the early host defence against HIV-1 infection, modulating the pathogenesis of acute HIV-1 infection (AHI). Emerging studies have identified tools for harnessing NK cell responses and expanding specialized NK subpopulations with adaptive/memory features, paving the way for development of novel HIV-1 therapeutics. This review highlights the knowns and unknowns regarding the role of NK cell subsets in the containment of acute HIV-1 infection, and summarizes recent advances in selectively augmenting NK cell functions through prophylactic and therapeutic interventions.
DOI：
10.4049/jimmunol.1400417
发表时间：
2014-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Shang L;Smith AJ;Duan L;Perkey KE;Qu L;Wietgrefe S;Zupancic M;Southern PJ;Masek-Hammerman K;Reeves RK;Johnson RP;Haase AT
通讯作者：
Haase AT