Specificity, promiscuity, and precursor frequency in immunoreceptors.
Specificity, promiscuity, and precursor frequency in immunoreceptors.
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DOI：
10.1016/j.coi.2013.07.001
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发表时间：
2013-10
影响因子：
7
通讯作者：
Vanessa Venturi;Brian D. Rudd;M. Davenport
中科院分区：
文献类型：
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作者：
Vanessa Venturi;Brian D. Rudd;M. Davenport
突出的‘通用’TCR序列，如NKT/MAIT，识别保守的病原体特征。在免疫识别中扮演‘共同’的近胚系TCR序列的角色。流行的TCR序列是由体细胞基因重组有效地产生的。免疫系统由不同的免疫细胞群体组成，这些免疫细胞群体利用不同水平的免疫受体，其特征是不同水平的特异性、多样性和在宿主内和整个群体中的流行。这些受体从先天细胞和先天类细胞(如NKT和MAIT细胞)使用的通用受体，到零星发生的T细胞上表达的受体。在这里，我们综述了最近的进展，了解分子机制，驱动观察到的光谱的T细胞受体在体内。
Highlights‘Universal’TCR sequences such as NKT/MAIT recognize conserved pathogen features.Role of ‘common’near-germline TCR sequences in immune recognition.Prevalent TCR sequences are efficiently produced by somatic gene recombination.The immune system is comprised of various immune cell populations that utilize a spectrum of immunoreceptors characterized by different levels of specificity, diversity, and prevalence within a host and across a population. These range from the universal receptors employed by both innate cells and innate-like cells, such as NKT and MAIT cells, through to receptors expressed on T cells with sporadic incidence. Here we review recent advances in understanding the molecular mechanisms that drive the observed spectra of T cell receptors in vivo.