Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia
Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia
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DOI：
10.1016/j.schres.2005.08.003
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发表时间：
2005-12-15
影响因子：
4.5
通讯作者：
Iwanami, A
中科院分区：
文献类型：
--
作者：
Kirihara, K;Araki, T;Iwanami, A
我们之前报道了听觉P300事件相关电位振幅降低与积极思维障碍严重程度之间的关联，通过对慢性精神分裂症患者样本的积极思维障碍综合指数进行评估。在这里，我们用一种不同的测量方法，思维障碍指数（TDI），在一个新的55名患者的更大样本中重复了这些发现。听觉P300振幅与TDI得分呈显著负相关。这种相关性在左颞区比在右颞区更为明显。这些结果进一步表明，信息处理的电生理异常可能是精神分裂症患者积极思维障碍的基础。(c) 2005 Elsevier B.V.版权所有
We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia. (c) 2005 Elsevier B.V. All rights reserved.