Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila.
Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila.
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DOI：
10.1083/jcb.201209129
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发表时间：
2013-03-18
期刊：
影响因子：
--
通讯作者：
Horne-Badovinac S
中科院分区：
文献类型：
--
作者：
Lewellyn L;Cetera M;Horne-Badovinac S
畸形通过一种似乎降低每个细胞后缘整合素水平的机制促进果蝇滤泡上皮中的单个细胞运动。复杂的器官形状是由单个细胞的协调作用产生的。果蝇卵室是一种类似器官的结构，随着其生长，它沿着其前后轴延长。这种形态发生取决于器官外上皮层（滤泡细胞）中一种不寻常的平面极性。有趣的是，这种上皮也会经历定向迁移，导致卵室绕其前后轴旋转。然而，平面极性和该组织中迁移之间的功能关系尚不清楚。我们之前曾报道过畸形激酶的突变会破坏卵泡细胞的平面极性。在这里，我们表明畸形在该系统中的主要作用是促进单个细胞的运动。畸形会降低基底表面的整合素水平，这可能会促进每个细胞后缘的分离。这些数据提供了对畸形在细胞迁移中保守作用的机制见解，并表明滤泡细胞平面极性可能是上皮内单个细胞迁移行为的新兴特性。
Misshapen promotes individual cell motility in the Drosophila follicular epithelium through a mechanism that appears to reduce integrin levels at each cell’s trailing edge. Complex organ shapes arise from the coordinate actions of individual cells. The Drosophila egg chamber is an organ-like structure that lengthens along its anterior–posterior axis as it grows. This morphogenesis depends on an unusual form of planar polarity in the organ’s outer epithelial layer, the follicle cells. Interestingly, this epithelium also undergoes a directed migration that causes the egg chamber to rotate around its anterior–posterior axis. However, the functional relationship between planar polarity and migration in this tissue is unknown. We have previously reported that mutations in the Misshapen kinase disrupt follicle cell planar polarity. Here we show that Misshapen’s primary role in this system is to promote individual cell motility. Misshapen decreases integrin levels at the basal surface, which may facilitate detachment of each cell’s trailing edge. These data provide mechanistic insight into Misshapen’s conserved role in cell migration and suggest that follicle cell planar polarity may be an emergent property of individual cell migratory behaviors within the epithelium.
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组织伸长需要振荡基底肌球蛋白网络的收缩。
影响因子：
21.3
作者：
He, Li;Wang, Xiaobo;Tang, Ho Lam;Montell, Denise J.
通讯作者：
Montell, Denise J.
影响因子：
5.3
作者：
Becker, E;Huynh-Do, U;Skolnik, EY
通讯作者：
Skolnik, EY
DOI：
10.1126/science.1199424
发表时间：
2011-02-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Haigo SL;Bilder D
通讯作者：
Bilder D
影响因子：
4.8
作者：
Fu, CA;Shen, M;Luo, Y
通讯作者：
Luo, Y
影响因子：
2.7
作者：
Martynovsky, Maria;Wong, Ming-Ching;Schwarzbauer, Jean E.
通讯作者：
Schwarzbauer, Jean E.