Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy.
Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy.
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DOI：
10.2174/1874104501307010023
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kitagishi Y
中科院分区：
文献类型：
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作者：
Matsuda S;Nakanishi A;Wada Y;Kitagishi Y
多种酶参与一组磷酸肌醇脂的磷酸化。由于它们在信号转导中的重要作用，磷酸化肌苷代谢失调是许多疾病的关键步骤。它们的功能丧失已被证明是各种癌变的早期事件，因此被认为是恶性前病变的生物标志物。此外，该通路中多个节点的遗传改变与其他几种疾病有关。因此，鉴于这种普遍参与许多疾病，调节这一途径的分子的发展已经在研究中开始。它们一直是广泛研究和药物发现活动的焦点。更好地了解分子之间的联系可以发现药物开发的新目标。
Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development.