Distribution of Choroidal Thinning in High Myopia, Diabetes Mellitus, and Aging: A Swept-Source OCT Study
Distribution of Choroidal Thinning in High Myopia, Diabetes Mellitus, and Aging: A Swept-Source OCT Study
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DOI：
10.1155/2019/3567813
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发表时间：
2019-08-15
影响因子：
1.9
通讯作者：
Pablo, Luis
中科院分区：
文献类型：
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作者：
de Asis Bartol-Puyal, Francisco;Isanta, Carlos;Pablo, Luis
目的。使用早期治疗糖尿病视网膜病变研究 (ETDRS) 网格和三维 (3D) 图比较年轻健康、老年健康、年轻高度近视和老年 2 型糖尿病 (T2D) 患者之间的黄斑脉络膜变薄情况。方法。一项前瞻性研究，包括 51 名健康年轻受试者的 102 只眼睛、30 名健康老年受试者的 60 只眼睛、12 名高度近视患者的 24 只眼睛和 55 名 T2D 患者的 110 只眼睛。使用扫频光学相干断层扫描 Triton DRI（拓普康公司，日本东京）检查脉络膜厚度 (CT)。使用软件算法自动分割脉络膜，并导出 6x6 mm 黄斑立方体的平均 CT 值。创建 3D 地图来表示 CT，并使用 ETDRS 网格比较其值。结果。年轻健康患者、老年健康患者、年轻高度近视患者和 T2D 患者的平均年龄分别为 27.31 +/- 3.95、66.41 +/- 7.54、27.69 +/- 3.89 和 66.48 +/- 7.59 岁。 CT 显示不均匀，因为上部和中央区域较厚。年轻健康个体的所有 ETDRS 扇区总是比其他人更厚（p < 0.05）。结果发现，随着年龄的增长，脉络膜变薄的部分变薄（减少103.28μm），高度近视的变薄的鼻下部分（减少86.19μm），T2D的变薄的颞部（减少55.57μm）。此外，健康受试者的脉络膜较厚的区域也变薄了。结论。 3D 地图可以进一步了解脉络膜的变化。年轻健康个体的脉络膜图案类似于山脉；随着年龄的增长，一座山峰；高度近视时，是一个倒转的峡谷；在古老的T2D中，山峦聚集。并非所有脉络膜区域都以类似的方式受到影响，因为这取决于病理学。健康受试者的区域越厚，任何病理情况下的区域就越薄。
Purpose. To compare the macular choroidal thinning between young healthy, aged healthy, young high myopic, and aged type 2 diabetic (T2D) patients using the Early Treatment Diabetic Retinopathy Study (ETDRS) grid and three-dimensional (3D) maps. Methods. A prospective study including 102 eyes of 51 healthy young subjects, 60 eyes of 30 healthy aged subjects, 24 eyes of 12 high myopic patients, and 110 eyes of 55 T2D patients. Choroidal thickness (CT) was examined with swept-source optical coherence tomography Triton DRI (Topcon Corporation, Tokyo, Japan). The choroid was automatically segmented using the software algorithm, and mean CT values of a 6x6 mm macular cube were exported. 3D maps were created to represent CT, and its values were compared using the ETDRS grid. Results. Mean age was 27.31 +/- 3.95, 66.41 +/- 7.54, 27.69 +/- 3.89, and 66.48 +/- 7.59 years in young healthy, aged healthy, young high myopic, and T2D patients, respectively. CT was not shown to be uniform, as superior and central zones were thicker. All ETDRS sectors were always thicker (p < 0.05) in young healthy individuals than in the others. It was found that the choroidal sector which got thinner was inferior in case of age (103.28 mu m decrease), inferior-nasal in high myopia (86.19 mu m decrease), and temporal in T2D (55.57 mu m decrease). In addition, the choroid got thinner in those regions where it was thicker in healthy subjects. Conclusions. 3D maps allow a further comprehension of choroidal changes. The choroidal pattern in young healthy individuals resembles a mountain range; with age, a mountain peak; in high myopia, an inverted gorge; and in aged T2D, gathered hills. Not all choroidal regions are affected in a similar way, as it depends on the pathology. The thicker the zone is in healthy subjects, the thinner it becomes with any pathology.