Modulating the development of E. coli biofilms with 2-aminoimidazoles
Modulating the development of E. coli biofilms with 2-aminoimidazoles
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DOI：
10.1016/j.bmcl.2010.08.075
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发表时间：
2010-11-01
影响因子：
2.7
通讯作者：
Melander, Christian
中科院分区：
文献类型：
--
作者：
Reed, Catherine S.;Huigens, Robert W., III;Melander, Christian
报道了20元2-氨基咪唑/三氮唑中试文库的合成。对文库的每个成员进行了筛选，以确定其抑制或促进大肠杆菌和鲍曼不动杆菌生物被膜发展的能力。从这个筛选中发现了对大肠杆菌具有选择性的2-氨基咪唑类化合物，其抑制生物膜形成的最好的抑制剂的IC(50)为13 mU M。在400亩M(C)2010 Elsevier Ltd.中，最有效的促进大肠杆菌生物被膜形成的因素促进了生物被膜的形成321%。
The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported. Each member of the library was screened for its ability to inhibit or promote biofilm development of either Escherichia coli and Acinetobacter baumannii. From this screen, E. coli-selective 2-aminoimidazoles were discovered, with the best inhibitor inhibiting biofilm development with an IC(50) of 13 mu M. The most potent promoter of E. coli biofilm formation promoted biofilm development by 321% at 400 mu M. (C) 2010 Elsevier Ltd. All rights reserved.