Breath volatolomics for diagnosing chronic rhinosinusitis.
Breath volatolomics for diagnosing chronic rhinosinusitis.
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DOI：
10.2147/ijn.s171488
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发表时间：
2018
影响因子：
8
通讯作者：
Haick H
中科院分区：
文献类型：
--
作者：
Broza YY;Braverman I;Haick H
慢性鼻-鼻窦炎(CRS)是初级保健医生治疗的最常见的慢性疾病之一。越来越多的人认识到CRS和鼻息肉病(NP)包括几个不同原因的疾病过程。因此，需要区分鼻窦炎的亚型，以便对患者进行适当的筛查，并提供个性化的医疗服务。为了满足这一需求，我们使用了基于分子修饰的金纳米颗粒或分子修饰的单壁碳纳米管的交叉反应纳米阵列，并结合模式识别来分析呼气样本。呼吸样本来自希勒亚菲医疗中心的三组志愿者(共71人)：CRS、NP和对照组。纳米阵列结果区分鼻窦炎患者和对照组的灵敏度为87%，特异度为83%，准确率为85%。该系统还很好地区分了亚群：1)CRS与对照组(76%敏感性，90%特异性)；2)CRS与NP(82%敏感性，71%特异性)；以及3)NP与对照组(71%敏感性，90%特异性)。这项初步研究表明，基于纳米阵列的呼气测试用于筛查人群鼻窦炎相关疾病是可行的。
Chronic rhinosinusitis (CRS) is one of the most common chronic diseases treated by primary care physicians. It is increasingly recognized that CRS and nasal polyposis (NP) comprise several disease processes with diverse causes. Hence, subgroups of sinusitis need to be differentiated so that patients can be screened appropriately and personalized medical treatment provided. To address this need, we use a cross-reactive nanoarray based on either molecularly modified gold nanoparticles or molecularly modified single-walled carbon nanotubes, combined with pattern recognition for analyzing breath samples. Breath samples were collected from three groups of volunteers (total 71) at the Hillel Yaffe Medical Center: CRS, NP, and control. Nanoarray results discriminated between patients with sinusitis and the control group with 87% sensitivity, 83% specificity, and 85% accuracy. The system also discriminated well between the subpopulations: 1) CRS vs control (76% sensitivity, 90% specificity); 2) CRS vs NP (82% sensitivity, 71% specificity); and 3) NP vs control (71% sensitivity, 90% specificity). This preliminary study shows that a nanoarray-based breath test for screening population for sinusitis-related conditions is feasible.